Regulatory role of APA in pulmonary fibrosis during aging
Description: PROJECT NARRATIVE Idiopathic Pulmonary Fibrosis (IPF) is a prevalent and deadly aging-related disease that is characterized by chronic, progressive, and irreversible fibrosis. In this proposal, an RNA regulation mechanism through a molecule named Nudt21 will be linked to STAT3 activation and the pathogenesis of pulmonary fibrosis in aging. This project can ultimately lead to discovery of new targets for the treatment of fibrosis in IPF patients.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R56
Start date: 2022-09-30
End date: 2024-08-31
Investigator: ZHENG CHEN
Institution: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Funded outputs count: 13
Funder award ID: R56AG076144
OpenAlex ID: G2183184019