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Molecular Control of Muscle Fuel Metabolism

Description: PROJECT NARRATIVE We are witnessing a pandemic in obesity-related diabetes. This project seeks to identify new mechanisms, molecules, and metabolic pathways in muscle to guide novel therapeutic approaches aimed at reducing the development of insulin resistance and progression to diabetes in the obese population. The proposed studies also show great promise for developing effective therapeutics to reduce the complications of diabetes including cardiovascular and liver disease.

Funder: National Institute of Diabetes and Digestive and Kidney Diseases

Funding type: research

Funder scheme: R01

Start date: 1992-09-30

End date: 2022-04-30

Investigator: DANIEL PATRICK KELLY

Institution: UNIVERSITY OF PENNSYLVANIA

Topic: Adipose Tissue and Metabolism

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

Funded outputs count: 64

Funder award ID: R01DK045416

OpenAlex ID: G3563672033

Multimodality Assessment of Heart Failure with Preserved Ejection Fraction Skeletal Muscle Reveals Differences in the Machinery of Energy Fuel Metabolism

2021 · Payman Zamani, Elizabeth A. Proto, et al. · ESC Heart Failure · 38

Peripheral Determinants of Oxygen Utilization in Heart Failure With Preserved Ejection Fraction

2020 · Payman Zamani, Elizabeth A. Proto, et al. · JACC Basic to Translational Science · 45

Loss of mitochondrial energetics is associated with poor recovery of muscle function but not mass following disuse atrophy

2019 · Michelle B. Trevino, Xiaolei Zhang, et al. · American Journal of Physiology-Endocrinology and Metabolism · 74

MondoA drives muscle lipid accumulation and insulin resistance

2019 · Byungyong Ahn, Shibiao Wan, et al. · JCI Insight · 39

Single-Nucleotide Polymorphism of the MLX Gene Is Associated With Takayasu Arteritis

2018 · Natsuko Tamura, Yasuhiro Maejima, et al. · Circulation Genomic and Precision Medicine · 19

Sarcolipin Signaling Promotes Mitochondrial Biogenesis and Oxidative Metabolism in Skeletal Muscle

2018 · Santosh K. Maurya, Jose L. Herrera, et al. · Cell Reports · 126

Skeletal muscle mitochondrial remodeling in exercise and diseases

2018 · Zhenji Gan, Tingting Fu, et al. · Cell Research · 287

Impaired Mitochondrial Energetics Characterize Poor Early Recovery of Muscle Mass Following Hind Limb Unloading in Old Mice

2018 · Xiaolei Zhang, Michelle B Trevino, et al. · The Journals of Gerontology Series A · 58

Molecular Mechanisms Underlying Cardiac Adaptation to Exercise

2017 · Rick B. Vega, John P. Konhilas, et al. · Cell Metabolism · 307

Skeletal muscle PGC-1β signaling is sufficient to drive an endurance exercise phenotype and to counteract components of detraining in mice

2017 · Samuel Lee, Teresa C. Leone, et al. · American Journal of Physiology-Endocrinology and Metabolism · 16

Cardiac nuclear receptors: architects of mitochondrial structure and function

2017 · Rick B. Vega, Daniel P. Kelly · Journal of Clinical Investigation · 73

Exercise Inducible Lactate Dehydrogenase B Regulates Mitochondrial Function in Skeletal Muscle

2016 · Xijun Liang, Lin Liu, et al. · Journal of Biological Chemistry · 105

Coupling of mitochondrial function and skeletal muscle fiber type by a miR‐499/Fnip1/AMPK circuit

2016 · Jing Liu, Xijun Liang, et al. · EMBO Molecular Medicine · 129

MondoA coordinately regulates skeletal myocyte lipid homeostasis and insulin signaling

2016 · Byungyong Ahn, Mangala M. Soundarapandian, et al. · Journal of Clinical Investigation · 70

Mitochondrial biogenesis and dynamics in the developing and diseased heart

2015 · Gerald W. Dorn, Rick B. Vega, et al. · Genes & Development · 469

Maintaining Ancient Organelles

2015 · Rick B. Vega, Julie L. Horton, et al. · Circulation Research · 146

PGC-1α activity in nigral dopamine neurons determines vulnerability to α-synuclein

2015 · Carine Ciron, Lu Zheng, et al. · Acta Neuropathologica Communications · 94

Mitochondrial function in melanoma

2014 · Nicholas Theodosakis, Goran Micevic, et al. · Archives of Biochemistry and Biophysics · 28

A Role for Peroxisome Proliferator-Activated Receptor γ Coactivator-1 in the Control of Mitochondrial Dynamics During Postnatal Cardiac Growth

2013 · Ola J. Martin, Ling Lai, et al. · Circulation Research · 212

A Role for Peroxisome Proliferator-activated Receptor γ Coactivator 1 (PGC-1) in the Regulation of Cardiac Mitochondrial Phospholipid Biosynthesis

2013 · Ling Lai, Miao Wang, et al. · Journal of Biological Chemistry · 86

Nuclear receptor/microRNA circuitry links muscle fiber type to energy metabolism

2013 · Zhenji Gan, John Rumsey, et al. · Journal of Clinical Investigation · 198

PGC1α Plays a Critical Role in TWEAK–Induced Cardiac Dysfunction

2013 · Jianru Shi, Bingbing Jiang, et al. · PLoS ONE · 33

Liver-Specific PGC-1beta Deficiency Leads to Impaired Mitochondrial Function and Lipogenic Response to Fasting-Refeeding

2012 · Kari T. Chambers, Zhouji Chen, et al. · PLoS ONE · 33

Perturbations in the gene regulatory pathways controlling mitochondrial energy production in the failing heart

2012 · Gregory Aubert, Rick B. Vega, et al. · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · 91

Transcriptional integration of mitochondrial biogenesis

2012 · Richard C. Scarpulla, Rick B. Vega, et al. · Trends in Endocrinology and Metabolism · 797