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Roles of microRNA in age-related disruption of tissue homeostasis

Description: Functional recovery of tissue stem cells by a specific growth factor has opened the possibility for the therapy of geriatric diseases. However, molecular mechanisms underlying the disruption of organismal homeostasis remains largely unknown. Previously, we have demonstrated that some of microRNAs are important for the regulation of stem cell functions. These results provided insight into its relationship to the stem cell aging. In this study, we first investigated molecular mechanisms underlying the stem cell aging. Based on the results of it, we next generated gene-modified mice that can induce the tissue-specific stem cell aging. We confirmed aging-like molecular dynamics in the specific tissues; therefore, our mouse might be a useful for aging studies.

Funder: Japan Society for the Promotion of Science

Amount: ¥4,810,000

Funding type: research

Funder scheme: Grant-in-Aid for Scientific Research (C)

Start date: 2016-04-01

End date: 2019-03-31

Investigator: Hayato Kaneda

Institution: Shiga University of Medical Science

Topic: MicroRNA in disease regulation

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Funded outputs count: 4

Funder award ID: 16K08602

OpenAlex ID: G4563019976