Ex vivo hematopoietic stem cell growth mediated by the heat shock response
Description: PROJECT NARRATIVE Transplantation of blood-forming stem cells can provide curative therapies for patients with diverse blood cancers, genetic and acquired anemias, bone marrow failure syndromes, immune deficiencies and autoimmune diseases. Unfortunately, even after decades of research, blood-forming stem cells cannot be well maintained or expanded outside the body, which has left many patients without a sufficient source of potentially life-saving stem cells. This proposal will examine if the inability to grow blood-forming stem cells outside the body is a consequence of dysregulated protein synthesis and homeostasis, and test if interventions that increase protein quality control and prevent the accumulation of misfolded proteins enable stem cell maintenance and expansion.
Funding type: research
Funder scheme: R01
Start date: 2020-03-01
End date: 2024-12-31
Investigator: ROBERT A.J. SIGNER
Institution: UNIVERSITY OF CALIFORNIA, SAN DIEGO
Funded outputs count: 6
Funder award ID: R01DK124775
OpenAlex ID: G6962174761