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Transcriptional Regulation of Autophagy in Promoting Proteostasis Upon Hormetic Stress

Description: PROJECT NARRATIVE Mild stress exposure can lead to hormetic benefits in many organisms, including via induction of the cell- recycling process of autophagy and improved protein homeostasis. However, the underlying mechanisms that ensure increased autophagy and improved proteostasis upon hormetic heat stress remain unclear. The proposed studies seek to identify such regulatory mechanisms, which may prove important for developing strategies to protect against human protein-folding diseases.
Funding type: research
Funder scheme: R21
Start date: 2018-08-15
End date: 2020-10-31
Investigator: CAROLINE KUMSTA
Institution: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
Subfield: Epidemiology
Field: Medicine
Funded outputs count: 10
Funder award ID: R21AG058038
OpenAlex ID: G4585865260
SAMS-1 coordinates HLH-30/TFEB and PHA-4/FOXA activities through histone methylation to mediate dietary restriction-induced autophagy and longevity
2022 · Chiao-Yin Lim, Huan-Ting Lin, et al. · Autophagy · 30
Autophagic receptor p62 protects against glycation‐derived toxicity and enhances viability
2020 · Gemma Aragonès, Kalavathi Dasuri, et al. · Aging Cell · 41
The selective autophagy receptor SQSTM1/p62 improves lifespan and proteostasis in an evolutionarily conserved manner
2020 · Ricardo Aparicio, Malene Hansen, et al. · Autophagy · 31
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Assessing Tissue-Specific Autophagy Flux in Adult Caenorhabditis elegans
2020 · Jessica T. Chang, Malene Hansen, et al. · Methods in molecular biology · 10
The autophagy receptor p62/SQST-1 promotes proteostasis and longevity in C. elegans by inducing autophagy
2019 · Caroline Kumsta, Jessica T. Chang, et al. · Nature Communications · 141
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Getting under the skin: Cuticle damage elicits systemic autophagy response in C. elegans
2019 · Caroline Kumsta, Malene Hansen · The Journal of Cell Biology
Faculty Opinions recommendation of Mitochondrial permeability uncouples elevated autophagy and lifespan extension.
2019 · Yvonne Nyathi · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
Faculty Opinions recommendation of Mitochondrial permeability uncouples elevated autophagy and lifespan extension.
2019 · David Friedman, Shrijal Shah · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
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Faculty Opinions recommendation of Mitochondrial permeability uncouples elevated autophagy and lifespan extension.
2019 · Björn Schumacher · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
Mitochondrial Permeability Uncouples Elevated Autophagy and Lifespan Extension
2019 · Ben Zhou, Johannes Kreuzer, et al. · Cell · 219
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