Award

Lipid-Mediated Control of Acetyl-CoA Metabolism in the Pathogenesis of NAFLD

Description: PROJECT NARRATIVE The proposed research is relevant to public health because the discovery of novel mechanisms that regulate hepatic and intestinal lipid and glucose metabolism will provide new insights into the pathogenesis and complications of non-alcoholic fatty liver disease. The proposed studies are relevant to the mission of the NIDDK because they are expected to identify new therapeutic strategies for the management of non-alcoholic fatty liver disease.
Funding type: research
Funder scheme: R01
Start date: 1996-02-01
End date: 2027-12-31
Investigator: DAVID E. COHEN
Institution: BRIGHAM AND WOMEN'S HOSPITAL
Funded outputs count: 56
Funder award ID: R01DK048873
OpenAlex ID: G9000914200
2026 · Shuiling Zhao, Stevens Bontemps, et al. · Molecular Metabolism
2026 · Sepideh Mikaeeli, David E Cohen · Gut · 1
2026 · S. Hani Najafi-Shoushtari, Karsten Suhre, et al. · Research Square
2025 · Sepideh Mikaeeli, David E. Cohen · Journal of Hepatology · 4
2024 · Molly Little, Eric A. Ortlund · Biochemical Society Transactions · 7
2023 · William P. Esler, David E. Cohen · Journal of Hepatology · 111
2023 · Samuel A. Druzak, Matteo Tardelli, et al. · Nature Communications · 11
2023 · Alfonso Rubio-Navarro, Nicolás Gómez-Banoy, et al. · Nature Cell Biology · 71
2021 · Arturo Mendoza, Catherine Tang, et al. · Science Signaling · 37
2020 · Tibor I. Krisko, Hayley T. Nicholls, et al. · Cell Metabolism · 77
2018 · Amir I. Mina, Raymond A. LeClair, et al. · Cell Metabolism · 464
2017 · Baran A. Ersoy, Kristal M. Maner-Smith, et al. · Journal of Clinical Investigation · 36
2017 · Samir Softic, Manoj K. Gupta, et al. · Journal of Clinical Investigation · 347
2017 · Colin J. Palmer, Raphael J. Bruckner, et al. · Molecular Metabolism · 68
2017 · Veronika Tillander, Stefan E.H. Alexson, et al. · Trends in Endocrinology and Metabolism · 183
2015 · Hamed Nayeb-Hashemi, Anal Desai, et al. · Biochemical and Biophysical Research Communications · 57
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