Amyloidogenic Induction of Cellular Senescence in Alzheimer's Disease
Description: PROJECT NARRATIVE One of the most well-known hallmarks of human aging is cellular senescence; however the relationship between senescence and Alzheimer’s Disease (AD) is poorly understood. We hypothesize that soluble amyloids, but not fibrils or plaques, link the induction of cellular senescence in brain cells to neurodegeneration, yet it remains unclear which soluble amyloids modulate these behaviors. In order to test this hypothesis, we will utilize a combination of genetic and epigenetic measurements to compare the ability of synthetic and patient-derived amyloids to induce senescence in brain cells, thereby deducing the molecular and epigenetic overlap between senescence and AD.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R01
Start date: 2020-08-01
End date: 2025-07-31
Investigator: ANDREW D. MIRANKER
Institution: YALE UNIVERSITY
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Funded outputs count: 13
Funder award ID: R01AG068285
OpenAlex ID: G6889093318