Award

Mechanisms and Impact of Osteoblast "Citration" on Skeletal Mineralization and Global Citrate Homeostasis

Description: PROJECT NARRATIVE Citrate is used by all aerobic organisms to produce usable chemical energy and is present in mineralized tissues (bone and teeth) at strikingly high concentrations. In this project, we will determine the mechanisms responsible for mineral citrate deposition in mice and men and the consequences of altered citrate handling by the osteoblast on tissue mineralization, citricemia and citruria, provoked by genetic mutations, pharmacologic interventions or in responds to endocrine cues. We believe our studies will validate a new metabolic pathway linking citrate metabolism to the biomechanical and physiological functions of mineralized tissues with the osteoblast as a central player.

Funder: National Institute of Arthritis and Musculoskeletal and Skin Diseases

Funding type: research

Funder scheme: R00

Start date: 2024-02-01

End date: 2027-08-31

Investigator: NAOMI DIRCKX (lead)

Institutions: Washington University in St. Louis, WASHINGTON UNIVERSITY

Topic: Alkaline Phosphatase Research Studies

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

Funded outputs count: 2