Role of senescent cells in uterine fibroid pathogenesis
Description: Uterine fibroids are prevalent tumors of uterus characterized by excessive fibrotic tissues. Using new cutting-edge computational methods, we have found that small groups of senescent cells in fibroids work in concert with immune cells to produce soluble factors in fibroid tissues to create a feed-forward loop leading to fibrosis. This project seeks to unravel key cell-cell communication networks involving senescent and immune cells in fibroids to develop new treatments for uterine fibroids.
Funding type: research
Funder scheme: R01
Start date: 2023-03-15
End date: 2027-12-31
Investigator: MOSTAFA A. BORAHAY
Institution: JOHNS HOPKINS UNIVERSITY
Funded outputs count: 24
Funder award ID: R01HD111243
OpenAlex ID: G9000879546