Identification of factors involved in the regulation of muscle regeneration in the senescent stem cell niche.
Description: Although numerous molecules have been demonstrated to be involved in the regulation of skeletal muscle regeneration and repair, they have yet to address issues such as skeletal muscle fibrosis and loss of muscle mass (sarcopenia) associated with aging. Therefore, in this study, we focused on the potential influences of the surrounding environment as possible factors affecting skeletal muscle cell differentiation. We postulated that the effects of hypoxia in skeletal muscle and fibroblasts in the environment where skeletal muscle exists are particularly important. We were able to demonstrate the possibility that hypoxia and fibroblasts influence myoblast differentiation using a cell culture system that we constructed. Furthermore, we performed whole transcriptome expression profiling to identify new molecules that affect myoblast differentiation.
Amount: ¥4,290,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2018-04-01
End date: 2024-03-31
Investigator: Taiko Sukezane
Institution: Kio University
Subfield: Molecular Biology
Domain: Life Sciences
Funded outputs count: 1
Funder award ID: 18K10730
OpenAlex ID: G466333869