Safer gene editing tools for Australian livestock and biotech industries
Description: Editing the genome of an organism in an efficient and safe fashion is critical for the livestock and biotechnology industries. While CRISPR-Cas9 has become the method of choice for genome editing, it is known to introduce unwanted "on-target" and "off-target" mutations, limiting its utility. To address this the CI team created a novel genome editing platform technology termed Crackling-CAST that is almost 100% accurate, while retaining the efficiency of the classical Cas9 system. This project will exemplify the capabilities of the novel gene targeting platform in cell types used by the biotechnology and livestock sectors, ensuring its global uptake by these industries and delivering significant economic benefits for Australia.
Funder: Australian Research Council
Amount: A$500,400
Funding type: research
Funder scheme: Discovery Projects
Start date: 2021-01-01
End date: 2025-03-01
Investigator: Ernst Wolvetang
Institution: The University of Queensland
Funded outputs count: 10
Funder award ID: DP210103401
OpenAlex ID: G4668895115