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2io1bx001355-01a2

Funded outputs count: 17
Funder award ID: 2IO1BX001355-01A2
OpenAlex ID: G4669566078
Metformin improves cardiac stress tolerance and mitochondrial function during early aging
2026 · Qun Chen, Jeremy Thompson, et al. · Experimental Gerontology
Calpain activation disrupts ER-Phagy and leads to mitochondrial damage in hearts treated with isoproterenol
2025 · Qun Chen, Ling Li, et al. · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
High-dose metformin treatment to inhibit complex I during early reperfusion protects the aged mouse heart via decreased mitochondrial permeability transition pore opening
2024 · Qun Chen, Jeremy Thompson, et al. · Journal of Pharmacology and Experimental Therapeutics · 4
Acute endoplasmic reticulum stress‐induced mitochondria respiratory chain damage: The role of activated calpains
2024 · Qun Chen, Ling Li, et al. · The FASEB Journal · 9
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COVID-19 and myocardial injury: Targeting elevated biomarkers for potential novel therapies
2024 · Pengyang Li, Qun Chen, et al. · Clinics
Endoplasmic reticulum stress and alterations of peroxiredoxins in aged hearts
2023 · Qun Chen, Jeremy Thompson, et al. · Mechanisms of Ageing and Development · 13
Endoplasmic reticulum stress and mitochondrial dysfunction during aging: Role of sphingolipids
2023 · Qun Chen, Anna Kovilakath, et al. · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · 26
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Reversing mitochondrial defects in aged hearts: role of mitochondrial calpain activation
2022 · Qun Chen, Jeremy Thompson, et al. · American Journal of Physiology-Cell Physiology · 20
Calpain-mediated protein targets in cardiac mitochondria following ischemia–reperfusion
2022 · Ling Li, Jeremy Thompson, et al. · Scientific Reports · 23
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Time to Target Mitochondrial Reactive Oxygen Species Generation from Complex I
2022 · Qun Chen, Edward J Lesnefsky · Function · 4
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Cerebral and myocardial mitochondrial injury differ in a rat model of cardiac arrest and cardiopulmonary resuscitation
2021 · Xianfei Ji, Jennifer L. Bradley, et al. · Biomedicine & Pharmacotherapy · 10
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Preventing Myocardial Injury Following Non-Cardiac Surgery: A Potential Role for Preoperative Antioxidant Therapy with Ubiquinone
2021 · Qun Chen, Steven Qi, et al. · Antioxidants · 11
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Endoplasmic reticulum stress-mediated mitochondrial dysfunction in aged hearts
2020 · Qun Chen, Arun Samidurai, et al. · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 80
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Remote Ischemic Pre-Conditioning Attenuates Adverse Cardiac Remodeling and Mortality Following Doxorubicin Administration in Mice
2019 · Zachary M. Gertz, Chad Cain, et al. · JACC CardioOncology · 23
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Inhibition of the ubiquitous calpains protects complex I activity and enables improved mitophagy in the heart following ischemia-reperfusion
2019 · Qun Chen, Jeremy Thompson, et al. · American Journal of Physiology-Cell Physiology · 64
Cardiac Specific Knockout of p53 Decreases ER Stress-Induced Mitochondrial Damage
2019 · Qun Chen, Jeremy Thompson, et al. · Frontiers in Cardiovascular Medicine · 32
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The lignan manassantin is a potent and specific inhibitor of mitochondrial complex I and bioenergetic activity in mammals
2017 · Yibao Ma, Hae-Ki Min, et al. · Journal of Biological Chemistry · 15
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