Get started
Award

R01 DK111542

Funded outputs count: 18
Funder award ID: R01 DK111542
OpenAlex ID: G470018328
Central Osmolality Sensing for Arginine Vasopressin Release Is Mediated by WNK1‐OSR1/SPAK‐Kv3.1 Cascade
2025 · Xin Jin, Jian Xie, et al. · The FASEB Journal · 2
PDF
Kidney-specific WNK1 amplifies kidney tubule responsiveness to potassium via WNK body condensates
2025 · Cary R. Boyd-Shiwarski, Rebecca T. Beacham, et al. · Journal of Clinical Investigation · 11
WNK1 mediates M-CSF-induced macropinocytosis to enforce macrophage lineage fidelity
2025 · Alissa J. Trzeciak, Zong-Lin Liu, et al. · Nature Communications · 4
PDF
Transport activity regulates mitochondrial bioenergetics and biogenesis in renal tubules
2024 · Chih‐Jen Cheng, Jonathan M. Nizar, et al. · The FASEB Journal · 10
PDF
WNK1 is required during male pachynema to sustain fertility
2023 · Ru-pin Alicia Chi, Xiaojiang Xu, et al. · iScience · 8
PDF
WNK1 promotes water homeostasis by acting as a central osmolality sensor for arginine vasopressin release
2023 · Xin Jin, Jian Xie, et al. · Journal of Clinical Investigation · 13
PDF
Chloride oscillation in pacemaker neurons regulates circadian rhythms through a chloride-sensing WNK kinase signaling cascade
2022 · Jeffrey N. Schellinger, Qifei Sun, et al. · Current Biology · 18
Impairment in renal medulla development underlies salt wasting in Clc-k2 channel deficiency
2021 · Meng-Hsuan Lin, Jen-Chi Chen, et al. · JCI Insight · 18
PDF
Chloride sensing by WNK1 regulates NLRP3 inflammasome activation and pyroptosis
2021 · Lindsey Mayes-Hopfinger, Aura Enache, et al. · Nature Communications · 99
PDF
L-WNK1 is required for BK channel activation in intercalated cells
2021 · Evan C. Ray, Rolando Carrisoza-Gaytan, et al. · American Journal of Physiology-Renal Physiology · 20
PDF
WNK1 regulates uterine homeostasis and its ability to support pregnancy
2020 · Ru-pin Alicia Chi, Tianyuan Wang, et al. · JCI Insight · 22
PDF
WNK1 Kinase Stimulates Angiogenesis to Promote Tumor Growth and Metastasis
2020 · Zong-Lin Sie, Ruei-Yang Li, et al. · Cancers · 50
PDF
Reply to Farfel et al.: Is enhanced chloride reabsorption in proximal tubule a possible mechanism of metabolic acidosis in PHAII?
2019 · Jen-Chi Chen, Shih-Hua Lin, et al. · Proceedings of the National Academy of Sciences
WNK4 kinase is a physiological intracellular chloride sensor
2019 · Jen-Chi Chen, Yi-Fen Lo, et al. · Proceedings of the National Academy of Sciences · 99
OSR1 regulates a subset of inward rectifier potassium channels via a binding motif variant
2018 · Clinton A. Taylor, Sung-Wan An, et al. · Proceedings of the National Academy of Sciences · 37
Differential roles of WNK4 in regulation of NCC in vivo
2018 · Yih-Sheng Yang, Jian Xie, et al. · American Journal of Physiology-Renal Physiology · 28
Potassium-regulated distal tubule WNK bodies are kidney-specific WNK1 dependent
2017 · Cary R. Boyd-Shiwarski, Daniel J. Shiwarski, et al. · Molecular Biology of the Cell · 84
New Insights into the Mechanism of Action of Soluble Klotho
2017 · George D. Dalton, Jian Xie, et al. · Frontiers in Endocrinology · 206
PDF
Year
Topic