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Contribution of the Unfolded Protein Response Signaling to Retinal Neural Circuits Function During Aging and Neurodegeneration.

Amount: CLP 218,200
Funding type: research
Funder scheme: FONDECYT - REGULAR
Start date: 2020-01-01
End date: 2024-12-31
Investigator: ADRIAN PALACIOS
Institution: UNIVERSIDAD DE VALPARAISO
Funded outputs count: 7
Funder award ID: 1200880
OpenAlex ID: G4753028688
Tag-and-Trigger: Basolateral Amygdala Stimulation Reinforces Behaviorally Tagged Hippocampus-Cortical Circuits to Enhance Memory Consolidation and Reverse Alzheimer's Disease Pathology in 5XFAD Mice
2026 · Daymara Mercerón-Martínez, Ricardo Ceriani, et al. · Research Square
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Diabetic retinopathy and Alzheimer's disease: Convergence of the unfolded protein response in neurodegeneration
2025 · Adrián G. Palacios, Sarah X. Zhang, et al. · Alzheimer s & Dementia · 15
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XBP1s as a Therapeutic Target to Preserve Retinal Function During Aging and Neurodegeneration
2025 · Leonel E. Medina, Joel Barría, et al. · bioRxiv (Cold Spring Harbor Laboratory)
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The unfolded protein response transcription factor XBP1s ameliorates Alzheimer’s disease by improving synaptic function and proteostasis
2023 · Claudia Duran-Aniotz, Natalia Poblete, et al. · Molecular Therapy · 60
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mGluR-dependent plasticity in rodent models of Alzheimer’s disease
2023 · Gonzalo Valdivia, Alvaro O. Ardiles, et al. · Frontiers in Synaptic Neuroscience · 11
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Multiscale entropy analysis of retinal signals reveals reduced complexity in a mouse model of Alzheimer’s disease
2022 · Joaquín Araya-Arriagada, Sebastián Garay, et al. · Scientific Reports · 6
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Ocular Health of Octodon degus as a Clinical Marker for Age-Related and Age-Independent Neurodegeneration
2021 · Lily Y. -L. Chang, Nicolas Palanca-Castan, et al. · Frontiers in Integrative Neuroscience · 9
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