Ectopic adiposity in black men with high type 2 diabetes risk
Description: PUBLIC HEALTH RELEVANCE: Obesity and type 2 diabetes (T2D) are escalating at alarming rates and disproportionately affect black individuals. Generalized obesity and other established risk factors do not explain the racial disparity in T2D, and this is particularly evident among men Emerging evidence indicates that fat accumulation in non-adipose tissues (referred to as ectopic adiposity) may be associated with T2D, independent of generalized obesity. In particular, skeletal muscle adiposity may be the key adipose tissue depot contributing to increased T2D risk in blacks. However, many important questions about the epidemiology of skeletal muscle adiposity remain unanswered, particularly among high-risk black men. We are proposing to continue and expand our research in a large, well-characterized high-risk cohort of black men, and address the following aims: characterize the natural history of skeletal muscle adiposity changes with aging in black men, and the temporal relationship of these changes with glucose and insulin homeostasis; test several compelling hypotheses about the etiology and consequences of skeletal muscle adiposity; and test for an association of abdominal skeletal muscle adiposity with measures of glucose and insulin homeostasis, independent of other ectopic adipose tissue depots. The proposed study will greatly advance our understanding of T2D among black men.
Funding type: research
Funder scheme: R01
Start date: 2013-09-19
End date: 2018-07-31
Investigator: IVA MILJKOVIC
Institution: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
Funded outputs count: 29
Funder award ID: R01DK097084
OpenAlex ID: G4609825828