Regulating microglia to combat hippocampal-dependent cognitive decline in ageing
Description: Age-related cognitive decline, a hallmark of dementia, coincides with reduced activity of neural precursor cells and reduced rate of neuron production in the hippocampus – a key brain structure for learning and memory. Importantly, we have demonstrated that exercise can activate neural precursor cells and boost the production of new neurons as well as improve learning and memory. This project will explore the cellular and molecular mechanisms behind these exercise-induced benefits on cognition.
Amount: A$493,800
Funding type: research
Funder scheme: Project Grants - New Investigator Grant
Start date: 2017-01-01
End date: 2020-12-31
Investigator: Jana Vukovic
Institution: University of Queensland
Funded outputs count: 6
Funder award ID: 1124503
OpenAlex ID: G4775466859