Ceramide-mediated pathology in periodontitis
Description: NARRATIVE We recently discovered new class of inflammatory ceramides, phosphoglycerol dihydroceramide (PGDHC) produced by Porphyromonas gingivalis, that is not only abundantly present in human periodontitis lesions, but also engaged in promotion of osteoclastogenesis. The proposed studies will investigate molecular mechanism underlying PGDHC-mediated pathologic bone resorption in periodontitis, in relation to the host-derived acid ceramidase that can potentially degrade PGDHC. Once our hypothesis is proven to be true, we will be well placed to develop a novel therapeutic approach for suppression of bone loss in P. gingivalis-associated periodontitis. .
Funding type: research
Funder scheme: R03
Start date: 2019-06-01
End date: 2021-09-30
Investigator: ALEXANDRU MOVILA
Institution: NOVA SOUTHEASTERN UNIVERSITY
Subfield: Molecular Biology
Domain: Life Sciences
Funded outputs count: 9
Funder award ID: R03DE027153
OpenAlex ID: G6058797251