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Muscle Protein Turnover and Amino Acid Uptake in Sepsis

Funding type: research
Funder scheme: R01
Start date: 1987-01-01
End date: 2011-09-30
Investigator: PER-OLOF J HASSELGREN
Institution: BETH ISRAEL DEACONESS MEDICAL CENTER
Funded outputs count: 111
Funder award ID: R01DK037908
OpenAlex ID: G2513254433
Suppression of atrogin-1 and MuRF1 prevents dexamethasone-induced atrophy of cultured myotubes
2013 · Estibaliz Castillero, Nima Alamdari, et al. · Metabolism · 88
PPARβ/δ Regulates Glucocorticoid- and Sepsis-Induced FOXO1 Activation and Muscle Wasting
2013 · Estibaliz Castillero, Nima Alamdari, et al. · PLoS ONE · 42
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CaMKII activity is reduced in skeletal muscle during sepsis
2012 · Zaira Aversa, Nima Alamdari, et al. · Journal of Cellular Biochemistry · 6
Loss of muscle strength during sepsis is in part regulated by glucocorticoids and is associated with reduced muscle fiber stiffness
2012 · Nima Alamdari, Gianluca Toraldo, et al. · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · 29
Acetylation and deacetylation—novel factors in muscle wasting
2012 · Nima Alamdari, Zaira Aversa, et al. · Metabolism · 71
β-Hydroxy-β-methylbutyrate (HMB) prevents dexamethasone-induced myotube atrophy
2012 · Zaira Aversa, Nima Alamdari, et al. · Biochemical and Biophysical Research Communications · 48
Multiple muscle wasting-related transcription factors are acetylated in dexamethasone-treated muscle cells
2012 · Wei Chamberlain, Patricia Gonnella, et al. · Biochemistry and Cell Biology · 22
Resveratrol prevents dexamethasone-induced expression of the muscle atrophy-related ubiquitin ligases atrogin-1 and MuRF1 in cultured myotubes through a SIRT1-dependent mechanism
2011 · Nima Alamdari, Zaira Aversa, et al. · Biochemical and Biophysical Research Communications · 97
Molecules modulating gene transcription during muscle wasting in cancer, sepsis, and other critical illness
2011 · Zaira Aversa, Nima Alamdari, et al. · Critical Reviews in Clinical Laboratory Sciences · 17
C/EBPβ regulates dexamethasone‐induced muscle cell atrophy and expression of atrogin‐1 and MuRF1
2011 · Patricia Gonnella, Nima Alamdari, et al. · Journal of Cellular Biochemistry · 33
CALPAIN activity is increased in skeletal muscle from gastric cancer patients with no or minimal weight loss
2011 · Ira J. Smith, Zaira Aversa, et al. · Muscle & Nerve · 56
Sepsis downregulates myostatin mRNA levels without altering myostatin protein levels in skeletal muscle
2010 · Ira J. Smith, Zaira Aversa, et al. · Journal of Cellular Biochemistry · 34
Sepsis and glucocorticoids downregulate the expression of the nuclear cofactor PGC-1β in skeletal muscle
2010 · Michael J. Menconi, Zoltan P. Arany, et al. · American Journal of Physiology-Endocrinology and Metabolism · 35
Sepsis and glucocorticoids upregulate p300 and downregulate HDAC6 expression and activity in skeletal muscle
2010 · Nima Alamdari, Ira J. Smith, et al. · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · 58
Corticosteroids and muscle wasting: role of transcription factors, nuclear cofactors, and hyperacetylation
2010 · Per-Olof Hasselgren, Nima Alamdari, et al. · Current Opinion in Clinical Nutrition & Metabolic Care · 94
Dexamethasone stimulates store-operated calcium entry and protein degradation in cultured L6 myotubes through a phospholipase A2-dependent mechanism
2010 · Kiyoshi Itagaki, Michael Menconi, et al. · American Journal of Physiology-Cell Physiology · 25
Sepsis increases the expression and activity of the transcription factor Forkhead Box O 1 (FOXO1) in skeletal muscle by a glucocorticoid-dependent mechanism
2010 · Ira J. Smith, Nima Alamdari, et al. · The International Journal of Biochemistry & Cell Biology · 90
Experimental hyperthyroidism in rats increases the expression of the ubiquitin ligases atrogin‐1 and MuRF1 and stimulates multiple proteolytic pathways in skeletal muscle
2009 · Patrick O'Neal, Nima Alamdari, et al. · Journal of Cellular Biochemistry · 21
When Initial Postexcision PTH Level Does Not Fall Appropriately During Parathyroidectomy: What to Do Next?
2009 · Patrick B. O’Neal, Vitaliy Poylin, et al. · World Journal of Surgery · 9
Curcumin and muscle wasting—A new role for an old drug?
2008 · Nima Alamdari, Patrick O'Neal, et al. · Nutrition · 70
Dexamethasone and corticosterone induce similar, but not identical, muscle wasting responses in cultured L6 and C2C12 myotubes
2008 · Michael Menconi, Patricia Gonnella, et al. · Journal of Cellular Biochemistry · 184
Calpain activity and muscle wasting in sepsis
2008 · Ira J. Smith, Stewart H. Lecker, et al. · American Journal of Physiology-Endocrinology and Metabolism · 138
The NF- κ B Inhibitor Curcumin Blocks Sepsis-Induced Muscle Proteolysis
2008 · Vitaliy Poylin, Moin U. Fareed, et al. · Mediators of Inflammation · 61
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The NF‐κB Inhibitor Curcumin Blocks Sepsis‐Induced Muscle Proteolysis
2008 · Vitaliy Poylin, Moin U. Fareed, et al. · Mediators of Inflammation · 10
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Role of glucocorticoids in the molecular regulation of muscle wasting
2007 · Michael Menconi, Moin Fareed, et al. · Critical Care Medicine · 115
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