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Endothelial Progenitor Cells and Particulate Air Pollution

Description: PROJECT NARRATIVE Acute exposure to particulate matter (PM) air pollution produces oxidative stress and inflammatory responses in young healthy adults and chronic exposures are strongly correlated with the progression of atherosclerosis, increased thrombosis, myocardial infarction, and stroke. In this proposal, we determine if the effects of PM are more pronounced in unhealthy, at risk populations with impaired anti-oxidant capacity and whether these effects can be limited by a simple anti-oxidant intervention.
Funding type: research
Funder scheme: R01
Start date: 2011-09-23
End date: 2024-03-31
Investigator: ARUNI BHATNAGAR
Institution: UNIVERSITY OF LOUISVILLE
Funded outputs count: 51
Funder award ID: R01ES019217
OpenAlex ID: G5022389793
Effects of carnosine supplementation on physical endurance: a placebo-controlled randomized clinical trial
2026 · Timothy E. O'Toole, Christopher J. Wingard, et al. · Journal of the International Society of Sports Nutrition
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Inhalation of concentrated ambient PM2.5 promotes inactivation of telomerase reverse transcriptase, telomere shortening, and senescence of multiple cell types in mice
2025 · Daniel Gomes, Jingjing Zhao, et al. · Toxicological Sciences · 4
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Carnosine supplementation improves cognitive outcomes in younger participants of the NEAT trial
2025 · Timothy E. O'Toole, Alok R. Amraotkar, et al. · Neurotherapeutics · 9
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Evaluation of supplementary carnosine accumulation and distribution: an initial analysis of participants in the Nucleophilic Defense Against PM Toxicity (NEAT) clinical trial
2024 · Shahid P. Baba, Alok R. Amraotkar, et al. · Amino Acids · 7
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Oral Polystyrene Consumption Potentiates Atherosclerotic Lesion Formation in ApoE −/− Mice
2024 · Jingjing Zhao, Daniel Gomes, et al. · Circulation Research · 24
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Comparative evaluation of different modalities for measuring in vivo carnosine levels
2024 · Alok R. Amraotkar, David Hoetker, et al. · PLoS ONE · 2
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Obesogenic polystyrene microplastic exposures disrupt the gut-liver-adipose axis
2024 · Jingjing Zhao, Ngozi Adiele, et al. · Toxicological Sciences · 41
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Big Data and ASCVD Risk Prediction
2022 · Khurram Nasir, Andrew DeFilippis · Journal of the American College of Cardiology · 2
Polystyrene bead ingestion promotes adiposity and cardiometabolic disease in mice
2022 · Jingjing Zhao, Daniel Gomes, et al. · Ecotoxicology and Environmental Safety · 110
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Environmental exposure to volatile organic compounds is associated with endothelial injury
2022 · Daniel W. Riggs, Marina V. Malovichko, et al. · Toxicology and Applied Pharmacology · 61
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Cardiovascular Effects of Particulate Air Pollution
2021 · Aruni Bhatnagar · Annual Review of Medicine · 235
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Impact of New ICD Codes on Acute MI Characteristics and Outcomes
2021 · Andrew P. DeFilippis, Michael E. Hall · Journal of the American College of Cardiology · 3
Exposure to Fine Particulate Matter Air Pollution Alters mRNA and miRNA Expression in Bone Marrow-Derived Endothelial Progenitor Cells from Mice
2021 · Xiaohong Li, Petra Haberzettl, et al. · Genes · 10
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Exposure to volatile organic compounds – acrolein, 1,3-butadiene, and crotonaldehyde – is associated with vascular dysfunction
2021 · Katlyn E. McGraw, Daniel W. Riggs, et al. · Environmental Research · 122
Endothelial progenitor cells as critical mediators of environmental air pollution-induced cardiovascular toxicity
2021 · Parul Singh, Timothy E. O’Toole, et al. · American Journal of Physiology-Heart and Circulatory Physiology · 40
Urinary Levels of the Acrolein Conjugates of Carnosine Are Associated with Cardiovascular Disease Risk
2021 · Timothy E. O’Toole, Xiaohong Li, et al. · International Journal of Molecular Sciences · 11
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Residential proximity to greenness mitigates the hemodynamic effects of ambient air pollution
2021 · Daniel W. Riggs, Ray Yeager, et al. · American Journal of Physiology-Heart and Circulatory Physiology · 50
Protocol to assess the efficacy of carnosine supplementation in mitigating the adverse cardiovascular responses to particulate matter (PM) exposure: the Nucleophilic Defense Against PM Toxicity (NEAT) trial
2020 · Timothy E. O"Toole, Alok A. Amraotkar, et al. · BMJ Open · 4
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Urinary levels of the acrolein conjugates of carnosine are associated with inhaled toxicants
2020 · Timothy E. O’Toole, Xiaohong Li, et al. · Inhalation Toxicology · 4
Tobacco Smoke and Endothelial Dysfunction: Role of Aldehydes?
2020 · Jordan Lynch, Lexiao Jin, et al. · Current Hypertension Reports · 28
Acute and chronic vascular effects of inhaled crotonaldehyde in mice: Role of TRPA1
2020 · Jordan Lynch, Lexiao Jin, et al. · Toxicology and Applied Pharmacology · 42
Tobacco product-derived aldehydes: effects on circulating angiogenic cells and implications for cardiovascular disease.
2020 · Jordan Lynch
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Association between residential greenness and exposure to volatile organic compounds
2019 · Ray Yeager, Daniel W. Riggs, et al. · The Science of The Total Environment · 52
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Exposure to airborne fine particulate matter is associated with impaired endothelial function and biomarkers of oxidative stress and inflammation
2019 · Daniel W. Riggs, Nagma Zafar, et al. · Environmental Research · 115
Carnosine Supplementation Mitigates the Deleterious Effects of Particulate Matter Exposure in Mice
2019 · Wesley Abplanalp, Petra Haberzettl, et al. · Journal of the American Heart Association · 30
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