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肝血窦内皮细胞可塑性对肝脏组织稳态的调控作用、机制和对肝纤维化的影响

Amount: ¥2,900,000
Funding type: research
Funder scheme: 重点项目
Start date: 2017-01-01
End date: 2022-12-31
Investigator: 骅 韩
Institution: 中国人民解放军第四军医大学
Funded outputs count: 25
Funder award ID: 31730041
OpenAlex ID: G4820742679
Repression of rRNA gene transcription by endothelial SPEN deficiency normalizes tumor vasculature via nucleolar stress
2023 · Zi-Yan Yang, Xian-Chun Yan, et al. · Journal of Clinical Investigation · 12
miR-342-5p promotes vascular smooth muscle cell phenotypic transition through a negative-feedback regulation of Notch signaling via targeting FOXO3
2023 · Ting Wen, Yanyan Duan, et al. · Life Sciences · 6
miR-342-5p downstream to Notch enhances arterialization of endothelial cells in response to shear stress by repressing MYC
2023 · Xiaoyan Zhang, Jiaxing Sun, et al. · Molecular Therapy — Nucleic Acids · 7
Exosome-mediated inhibition of microRNA-449a promotes the amplification of mouse retinal progenitor cells and enhances their transplantation in retinal degeneration mouse models
2023 · Chen Jun Guo, Xiu Li Cao, et al. · Molecular Therapy — Nucleic Acids · 8
RNA-binding protein SPEN controls hepatocyte maturation via regulating Hnf4α expression during liver development
2022 · Jiayulin Zhang, Ziyan Yang, et al. · Biochemical and Biophysical Research Communications · 1
The versatility of macrophage heterogeneity in liver fibrosis
2022 · Chun-Chen Gao, Jian Bai, et al. · Frontiers in Immunology · 37
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MicroRNA-582-5p Contributes to the Maintenance of Neural Stem Cells Through Inhibiting Secretory Protein FAM19A1
2022 · Yu-Fei Zhang, Xin-Xin Li, et al. · Frontiers in Cellular Neuroscience · 3
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miR-582 negatively regulates pre-B cell proliferation and survival through targeting Hif1α and Rictor
2022 · Xinxin Li, Yufei Zhang, et al. · Cell Death and Disease · 11
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Notch activation suppresses endothelial cell migration and sprouting via miR-223-3p targeting Fbxw7
2022 · Ruonan Wang, Ziyan Yang, et al. · In Vitro Cellular & Developmental Biology - Animal · 13
Transmembrane Protein Ttyh1 Maintains the Quiescence of Neural Stem Cells Through Ca2+/NFATc3 Signaling
2021 · Yuan Cao, Hai-ning Wu, et al. · Frontiers in Cell and Developmental Biology · 11
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Shear stress–induced cellular senescence blunts liver regeneration through Notch–sirtuin 1–P21/P16 axis
2021 · Juan‐Li Duan, Bai Ruan, et al. · Hepatology · 143
Notch activation promotes endothelial quiescence by repressing MYC expression via miR-218
2021 · Jia-Xing Sun, Guo-Rui Dou, et al. · Molecular Therapy — Nucleic Acids · 18
Capillarized Liver Sinusoidal Endothelial Cells Undergo Partial Endothelial-Mesenchymal Transition to Actively Deposit Sinusoidal ECM in Liver Fibrosis
2021 · Bai Ruan, Juan-Li Duan, et al. · Frontiers in Cell and Developmental Biology · 69
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Temozolomide Treatment Induces HMGB1 to Promote the Formation of Glioma Stem Cells via the TLR2/NEAT1/Wnt Pathway in Glioblastoma
2021 · Xiang-Yu Gao, Jian Zang, et al. · Frontiers in Cell and Developmental Biology · 49
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MicroRNAs in the Pathogenesis of Nonalcoholic Fatty Liver Disease
2021 · Zhiqiang Fang, Guorui Dou, et al. · International Journal of Biological Sciences · 79
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Disruption of myofibroblastic Notch signaling attenuates liver fibrosis by modulating fibrosis progression and regression
2021 · Zhensheng Yue, Zijian Jiang, et al. · International Journal of Biological Sciences · 37
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Adenovirus infection promotes the formation of glioma stem cells from glioblastoma cells through the TLR9/NEAT1/STAT3 pathway
2020 · Jian Zang, Min-Hua Zheng, et al. · Cell Communication and Signaling · 48
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SM22α+ vascular mural cells are essential for vessel stability in tumors and undergo phenotype transition regulated by Notch signaling
2020 · Xinxin Zhang, Xianchun Yan, et al. · Journal of Experimental & Clinical Cancer Research · 15
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Comparison of different calcium supplementation methods in patients with osteoporosis
2019 · Sheng‑Kai Ye, Xia Ren, et al. · Experimental and Therapeutic Medicine · 2
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Neurons can upregulate Cav-1 to increase intake of endothelial cells-derived extracellular vesicles that attenuate apoptosis via miR-1290
2019 · Kang-Yi Yue, Pei-Ran Zhang, et al. · Cell Death and Disease · 92
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NOTCH Signaling via WNT Regulates the Proliferation of Alternative, CCR2-Independent Tumor-Associated Macrophages in Hepatocellular Carcinoma
2019 · Yu-Chen Ye, Jun-Long Zhao, et al. · Cancer Research · 106
Transmembrane protein 215 promotes angiogenesis by maintaining endothelial cell survival
2018 · Yuan Liu, Qijun Zheng, et al. · Journal of Cellular Physiology · 17
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A fusion protein composed of the DSL domain of Dll1 and RGD motif protects cryptic stem cells in irradiation injury
2018 · Zhi-Jian Sun, Yi-Zhe Zhang, et al. · Bioscience Reports · 3
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Endothelial Notch activation reshapes the angiocrine of sinusoidal endothelia to aggravate liver fibrosis and blunt regeneration in mice
2018 · Juan‐Li Duan, Bai Ruan, et al. · Hepatology · 154
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Exosomes derived from human umbilical vein endothelial cells promote neural stem cell expansion while maintain their stemness in culture
2017 · Yi-Zhe Zhang, Fan Liu, et al. · Biochemical and Biophysical Research Communications · 32
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