Jetlag and neurodegeneration: Investigating the effects of Circadian desynchrony on Alzheimer’s disease pathogenesis
Description: This study investigates how disrupted circadian rhythms, common in aging and Alzheimer’s disease (AD), impact disease progression using a mouse model of chronic jetlag (CJL). With two main goals, it aims to understand how CJL affects AD markers—amyloid plaques and tau protein accumulation. Investigating the connection between circadian disruption, glial function, and AD-related changes may reveal therapeutic strategies. Insights gained may offer novel approaches to AD prevention, crucial given the widespread circadian desynchrony in modern society, with implications for public health.
Funder: BrightFocus Foundation
Amount: $200,000
Funding type: research
Funder scheme: Alzheimer's Disease Research: Standard
Start date: 2024-07-01
End date: 2027-06-30
Investigators: Ashish Sharma, Ashish Sharma
Institution: Washington University in St. Louis
Funded outputs count: 1
Funder award ID: A2024031F
OpenAlex ID: G4881161987