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Analysis of phagocytic activity of aging macrophage and the accompanying inflammatory response induced by apoptotic cells

Description: In this study, we investigated the mechanism of the decrease in phagocytic ability of macrophages accompanying aging. It was found that resident macrophages become pre-activated with aging, and their phagocytic ability decreases. In addition, it was suggested that the activation does not depend on the aging environment of the individual, but is caused by cell aging, and it was clarified that inactivation of p53 is involved in part of it.

Funder: Japan Society for the Promotion of Science

Amount: ¥4,420,000

Funding type: research

Funder scheme: Grant-in-Aid for Scientific Research (C)

Start date: 2018-04-01

End date: 2022-03-31

Investigator: Kisaburo NAGATA

Institution: Toho University

Topic: Phagocytosis and Immune Regulation

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences