Succinate triggers gut dysbiosis and activates SUCNR1 to enhance inflammaging
Description: Project Narrative The proposed study is focused on defining the aging-related metabolite alteration that influence microbiome composition and activating pro-inflammatory signaling which will help in understanding how the aging microbiome relates to the causes and pathophysiology of age-related chronic inflammation.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R01
Start date: 2020-08-15
End date: 2026-04-30
Investigator: XIN LI
Institution: UNIVERSITY OF VIRGINIA
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Funded outputs count: 7
Funder award ID: R01AG068857
OpenAlex ID: G616749235