Genetic analysis in the life prolonging effect of low dose radiation, and applications as biomarkers
Description: In the p53 gene normal 8-week-old mice, lifespan in the 2cGy+3Gy irradiated group extended than 3Gy alone irradiated group. There was no life-prolonging effect in p53 gene heterozygous mice (half the amount of p53) and 40-week-old mice. Expression of the p53 gene decreased at 40 weeks compared to 8 weeks of age, and there was no difference in the development of apoptosis between the 2cGy + 3Gy group and the 3Gy group. In the analysis of microRNAs that play an important role in biological phenomena, the microRNAs expressed in each irradiation group of 0Gy, 2cGy, 2cGy + 3Gy, and 3Gy were different. It was suggested that microRNAs could be biomarkers.
Amount: ¥4,420,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2018-04-01
End date: 2021-03-31
Investigator: RYUJI OKAZAKI
Institution: University of Occupational and Environmental Health, Japan
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Funded outputs count: 4
Funder award ID: 18K07774
OpenAlex ID: G488786703