Award

Organ banking for transplant--kidney cryopreservation by vitrification and novel nanowarming technology

Description: PROJECT NARRATIVE We are developing a novel technology for indefinitely preserving donor kidneys for transplant in an extremely low-temperature, vitrified (glass-like) state and subsequently rewarming them on-demand using nanotechnology. This method for cryopreserving or “banking” kidneys prior to transplant will allow a new paradigm for transplantation that improves donor/recipient matching, allows for better patient preparation, facilitates tolerance induction protocols, and increases organ utilization; all while improving kidney durability and patient survival.
Funding type: research
Funder scheme: R01
Start date: 2018-04-13
End date: 2027-03-31
Investigator: JOHN C BISCHOF
Institution: UNIVERSITY OF MINNESOTA
Funded outputs count: 45
Funder award ID: R01DK117425
OpenAlex ID: G9000871840
2026 · Zonghu Han, Bat-Erdene Namsrai, et al. · bioRxiv (Cold Spring Harbor Laboratory)
2026 · Casey Kraft, John C. Bischof, et al. · Frontiers in Cardiovascular Medicine
2026 · Michael G. Megaly, Diane Tobolt, et al. · Bioengineering & Translational Medicine
2026 · Lakshya Gangwar, Dorothy Haggard, et al. · Cryobiology
2026 · Onyinyechukwu Justina Oziri, Cameron Scheithauer, et al. · Journal of Nanobiotechnology · 3
2025 · Lakshya Gangwar, Dorothy Haggard, et al. · Cryobiology
2025 · Lakshya Gangwar, Zonghu Han, et al. · Nature Communications · 26
2025 · Onyinyechukwu Justina Oziri, Joseph Sushil Rao, et al. · Small · 8
2025 · Srivasupradha Ramesh, Joseph Sushil Rao, et al. · Bioengineering & Translational Medicine · 5
2025 · Insia Kizilbash, Minneapolis, MN, USA, et al.
2024 · Timothy L. Pruett, Susan M. Wolf, et al. · American Journal of Transplantation · 3
2023 · Casey J. Kraft, Bat-Erdene Namsrai, et al. · Cryobiology · 6
2023 · Lakshya Gangwar, Zonghu Han, et al. · Cryobiology · 1
2023 · Zonghu Han, Joseph Sushil Rao, et al. · Annals of Biomedical Engineering · 20
2023 · Ozge Sila Ozgur, Bat-Erdene Namsrai, et al. · Frontiers in Transplantation · 29
2023 · Jacqueline L. Pasek-Allen, Randall K. Wilharm, et al. · ACS Omega · 64
2023 · Han, Zonghu, Rao, Joseph Sushil, et al. · Institutional Repository of Leibniz Universität Hannover (Leibniz Universität Hannover)
2022 · Lakshya Gangwar, Shaunak S. Phatak, et al. · Cryoletters · 15
2022 · L Gangwar, S S Phatak, et al. · PubMed · 3
2022 · Li Zhan, Zonghu Han, et al. · Nature Communications · 53
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