Development of nutritional support by preventing and improving three-dimensional vascular disorders in diabetes
Description: Beneficial effects of nutritional supplements on the regression of three-dimensional capillary network in diabetic tissues were investigated in the present study. We investigated that these extracts administration could be used to prevent the regression of capillary network in skeletal muscle of animal models. The administration increased capillary luminal diameter, capillary volume, eNOS, and VEGF protein expression levels in the skeletal muscle of animal model. A chronic decrease results in capillary regression that are due, in part, to the overproduction of reactive oxygen species (ROS). antioxidant treatments with the extracts from algae, bee products, and/or salmon testes attenuated the overexpression of ROS in muscles and ameliorated the regression of capillary network. The results indicate that food extract supplementation is an important to prevent three-dimensional microvascular network disorders.
Amount: ¥3,510,000
Funding type: research
Funder scheme: Grant-in-Aid for Challenging Exploratory Research
Start date: 2016-04-01
End date: 2020-03-31
Investigator: Hiroyo Kondo
Institution: Nagoya Women's University
Funded outputs count: 8
Funder award ID: 16K12732
OpenAlex ID: G4917872644