Understanding the effects of Gender Affirming Hormone Therapy (GAHT) on immune function using a systems immunology approach
Description: PROJECT NARRATIVE One million individuals in the United States identify as transgender (0.39% of population), of which 90% are either on gender-affirming hormone therapy (GAHT) or considering starting GAHT. In this project we will apply a systems immunology approach to explore how GAHT affects immune function at the cellular, metabolic, and epigenetic level. Considering the high rates of HIV infection in transgender women in the United States, understanding how GAHT influences immune function and susceptibility to infection is relevant to public health, while in the longer-term potential immune signalling pathways can be therapeutically targeted to improve immune function during GAHT.
Funding type: research
Funder scheme: R21
Start date: 2023-08-22
End date: 2025-07-31
Investigator: BORIS NOVAKOVIC
Institution: MURDOCH CHILDREN'S RESEARCH INSTITUTE
Funded outputs count: 4
Funder award ID: R21AI179004
OpenAlex ID: G6258116169