Aging Auditory System: Presbycusis and Its Neural Bases
Description: PUBLIC HEALTH RELEVANCE: Presbycusis, or Age -Related Hearing Loss (ARHL), is the number one communication disorder and number one neurodegenerative condition of our expanding aging population; and comprises one of the top 3 chronic medical conditions, along with arthritis and cardiovascular diseases. The vast majority of people over age 60 are affected by this progressive decline in auditory sensitivity and speech understanding, which are hallmarks of ARHL. Despite this high prevalence of ARHL, there currently are no medical treatments for preventing or reversing permanent hearing loss (ARHL or other types). The thematic focus of this application is modulation of presbycusis through biotherapeutics and acoustic treatments. If the experiments proposed here to test hypotheses concerning interventions to modulate the progression of presbycusis are successful, the novel results should lead to FDA clinical trials of the efficacy of these innovative technological, acoustic and drug- related treatments.
Funder: National Institute on Aging
Funding type: program
Funder scheme: P01
Start date: 1992-05-01
End date: 2023-02-28
Investigator: ROBERT D FRISINA
Institution: UNIVERSITY OF SOUTH FLORIDA
Subfield: Sensory Systems
Field: Neuroscience
Domain: Life Sciences
Funded outputs count: 154
Funder award ID: P01AG009524
OpenAlex ID: G8392097152