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基于活性导向思路和代谢组学技术研究鞣花鞣质代谢物Urolithins的化学修饰及其代谢转运与调控

Amount: ¥600,000
Funding type: grant
Funder scheme: 面上项目
Start date: 2017-01-01
End date: 2021-12-31
Investigator: 本宏 周
Institution: 武汉大学
Funded outputs count: 23
Funder award ID: 31770381
OpenAlex ID: G4932236428
Design, synthesis and biological evaluation of novel urolithin derivatives targeting liver cancer cells
2025 · Mi Tian, Lirong Zhao, et al. · Journal of Enzyme Inhibition and Medicinal Chemistry · 3
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Methylated urolithin a attenuates lipopolysaccharide-induced memory impairment and behavioral disorders by inhibiting mitochondrial inflammation through the Drp1/HK1/NLRP3 pathway
2025 · Peng Chen, Wenhao Xiao, et al. · Journal of Functional Foods
Urolithin A alleviates schizophrenic-like behaviors and cognitive impairment in rats through modulation of neuroinflammation, neurogenesis, and synaptic plasticity
2025 · Zhengyuan Huang, Zhongyu Ren, et al. · Scientific Reports · 5
Neuroprotective Potential of Punicalagin, a Natural Component of Pomegranate Polyphenols: A Review
2023 · Peng Chen, ZhiLei Guo, et al. · Journal of Integrative Neuroscience · 16
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Disease-Associated Oligodendrocyte: New Player in Alzheimer's Disease and CNS Pathologies
2023 · Peng Chen, ZhiLei Guo, et al. · Journal of Integrative Neuroscience · 24
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Insight into the role of adult hippocampal neurogenesis in aging and Alzheimer's disease
2022 · Peng Chen, ZhiLei Guo, et al. · Ageing Research Reviews · 35
Recent Advances and Perspectives on the Health Benefits of Urolithin B, A Bioactive Natural Product Derived From Ellagitannins
2022 · Peng Chen, Zhiei Guo, et al. · Frontiers in Pharmacology · 54
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Understanding the Role of Glia-Neuron Communication in the Pathophysiology of Epilepsy: A Review
2022 · Peng Chen, Fuchao Chen, et al. · Journal of Integrative Neuroscience · 20
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Urolithin A alleviates acute kidney injury induced by renal ischemia reperfusion through the p62‐Keap1‐Nrf2 signaling pathway
2022 · Yi Zhang, Mengmeng Liu, et al. · Phytotherapy Research · 42
New Insights Into the Role of Aberrant Hippocampal Neurogenesis in Epilepsy
2021 · Peng Chen, Fuchao Chen, et al. · Frontiers in Neurology · 18
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The Gut Microbiota Metabolite Urolithin B Improves Cognitive Deficits by Inhibiting Cyt C-Mediated Apoptosis and Promoting the Survival of Neurons Through the PI3K Pathway in Aging Mice
2021 · Peng Chen, Fuchao Chen, et al. · Frontiers in Pharmacology · 36
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Letter: a randomised clinical trial comparing the effects of pregabalin with those of placebo on functional dyspepsia
2021 · Peng Chen, Fuchao Chen, et al. · Alimentary Pharmacology & Therapeutics · 1
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The Gut Microbiota Metabolite Urolithin B Improves Cognitive Deficits by Inhibiting Cyt C-mediated Apoptosis and Promoting the Survival of Neurons Through the PI3K Pathway in Aging Mice
2021 · chen peng, Fuchao Chen, et al. · Research Square · 18
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The Tannins from Sanguisorba officinalis L. (Rosaceae): A Systematic Study on the Metabolites of Rats Based on HPLC–LTQ–Orbitrap MS2 Analysis
2021 · Jingjing Tu, Qiaoling Li, et al. · Molecules · 17
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Urolithin A attenuates renal fibrosis by inhibiting TGF-β1/Smad and MAPK signaling pathways
2021 · Zhenzhen Cheng, Jingjing Tu, et al. · Journal of Functional Foods · 16
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Oral absorption mechanism of the polysaccharides from Gastrodia elata Blume base on fluorescence labeling
2021 · Baiyu Zhang, Mengmeng Liu, et al. · Food Research International · 61
Gut microbial metabolite urolithin B attenuates intestinal immunity function in vivo in aging mice and in vitro in HT29 cells by regulating oxidative stress and inflammatory signalling
2021 · Peng Chen, Fuchao Chen, et al. · Food & Function · 41
Clinical Characteristics of COVID-19 in Patients With Liver Injury
2020 · Peng Chen, Benhong Zhou · Clinical Gastroenterology and Hepatology · 12
Letter: corticosteroid use alongside tofacitinib in OCTAVE Open
2020 · Chen Peng, Lei Jiexin, et al. · Alimentary Pharmacology & Therapeutics · 3
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Clinical characteristics of COVID-19 patients with abnormal liver tests
2020 · Peng Chen, Benhong Zhou · Journal of Hepatology · 20
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Ameliorative effect of urolithin A on d -gal-induced liver and kidney damage in aging mice via its antioxidative, anti-inflammatory and antiapoptotic properties
2020 · Peng Chen, Jiexin Lei, et al. · RSC Advances · 36
Anti-renal fibrosis and anti-inflammation effect of urolithin B, ellagitannin-gut microbial-derived metabolites in unilateral ureteral obstruction rats
2019 · Qiaoling Li, Kuangyu Li, et al. · Journal of Functional Foods · 23
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Activation of the miR-34a-Mediated SIRT1/mTOR Signaling Pathway by Urolithin A Attenuates d-Galactose-Induced Brain Aging in Mice
2019 · Peng Chen, Fuchao Chen, et al. · Neurotherapeutics · 210
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