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A pathway to translation: uncovering novel causes, genetic associations and potential intervention strategies for age related macular degeneration

Description: Age-related macular degeneration (AMD) is the leading cause of vision loss in older individuals. AMD eyes with Reticular pseudo drusen (RPD) are newly recognised as at high-risk with faster AMD progression to vision loss. Identifying the genes that associate with RPD will provide a significant leap forward in our understanding of their cause and offer potential therapeutic options. Combining a world leading, multidiscipline team we will start a targeted search for these new genetic associations.
Amount: A$5,000,000
Funding type: research
Funder scheme: Synergy Grants - Synergy Grants
Investigator: Robyn Guymer
Institution: Centre for Eye Research Australia
Funded outputs count: 21
Funder award ID: 1181010
OpenAlex ID: G4950617487
Patient induced pluripotent stem cells identify specificities of a reticular pseudodrusen phenotype in age-related macular degeneration
2026 · Jenna C. Hall, Kavitha Krishna Sudhakar, et al. · Genome Medicine · 1
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Ground Truth Reliability and Clinical Generalisability in Deep Learning for Reticular Pseudodrusen—Response
2026 · Himeesh Kumar, Yelena Bagdasarova, et al. · Clinical and Experimental Ophthalmology
HTRA1/lncRNA HTRA1-AS1 dominates in age-related macular degeneration reticular pseudodrusen genetic risk with no complement involvement
2025 · Samaneh Farashi, Carla J. Abbott, et al. · Nature Communications · 2
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Deep Learning‐Based Detection of Reticular Pseudodrusen in Age‐Related Macular Degeneration
2025 · Himeesh Kumar, Yelena Bagdasarova, et al. · Clinical and Experimental Ophthalmology · 8
Multi-omic spatial effects on high-resolution AI-derived retinal thickness
2025 · V. E. Jackson, Y. Wu, et al. · Nature Communications · 39
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Genetic Risk of Reticular Pseudodrusen in Age-Related Macular Degeneration: HTRA1 /lncRNA BX842242.1 dominates, with no evidence for Complement Cascade involvement
2024 · Samaneh Farashi, Carla J Abbott, et al. · medRxiv · 8
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Pharmaceutical therapies targeting autophagy for the treatment of age-related macular degeneration
2024 · Kirstan A. Vessey, Andrew I. Jobling, et al. · Current Opinion in Pharmacology · 5
Decreased Circulating Very Small Low-Density Lipoprotein is Likely Causal for Age-Related Macular Degeneration
2024 · Samaneh Farashi, Roberto Bonelli, et al. · Ophthalmology Science · 2
Inter-night variability of in-home, overnight pulse oximetry screening in an asymptomatic older adult population
2024 · Attiqa Chaudhary, Carla J. Abbott, et al. · Sleep And Breathing · 2
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Drusen and Other Retinal Findings in People With IgA Glomerulonephritis
2023 · Ursula Greferath, Erica Fletcher, et al. · American Journal of Ophthalmology · 3
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A semi-automated pipeline for quantifying drusen-like deposits in human induced pluripotent stem cell-derived retinal pigment epithelium cells
2023 · Jenna Hall, Maciej Daniszewski, et al. · SLAS TECHNOLOGY · 4
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The retinal RNA editome is concentrated in photoreceptor-specific genes and genetically linked to vision loss
2023 · B RE Ansell, R Bonelli, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 2
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A village in a dish model system for population-scale hiPSC studies
2023 · Drew R. Neavin, Angela M. Steinmann, et al. · Nature Communications · 72
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Reticular Pseudodrusen: Interreader Agreement of Evaluation on OCT Imaging in Age-Related Macular Degeneration
2023 · Zhichao Wu, Steffen Schmitz-Valckenberg, et al. · Ophthalmology Science · 17
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Role of sleep-disordered breathing in age-related macular degeneration
2023 · Wendy Ying Fang, Palaniraj Rama Raj, et al. · BMJ Open Ophthalmology · 7
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Exploring the pathogenesis of age-related macular degeneration: A review of the interplay between retinal pigment epithelium dysfunction and the innate immune system
2022 · Josephine H. C. Wong, Jessica Y. W. Ma, et al. · Frontiers in Neuroscience · 108
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Transcriptomic and proteomic retinal pigment epithelium signatures of age-related macular degeneration
2022 · Anne Senabouth, Maciej Daniszewski, et al. · Nature Communications · 69
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Treatments targeting autophagy ameliorate the age-related macular degeneration phenotype in mice lacking APOE (apolipoprotein E)
2022 · Kirstan A Vessey, Andrew I Jobling, et al. · Autophagy · 48
Genetics of reticular pseudodrusen in age-related macular degeneration
2022 · Samaneh Farashi, Brendan R.E. Ansell, et al. · Trends in Genetics · 7
A clinical perspective on the expanding role of artificial intelligence in age-related macular degeneration
2022 · Himeesh Kumar, Kai Lyn Goh, et al. · Clinical and Experimental Optometry · 6
Transcriptomic Profiling of Human Pluripotent Stem Cell-Derived Retinal Pigment Epithelium over Time
2020 · Grace E. Lidgerwood, Anne Senabouth, et al. · Genomics Proteomics & Bioinformatics · 50
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