Analysis of the molecular basis of atypical cell-death induction with vacuolar formation in cancer cells by CDK4/6 inhibitors
Description: CDK4/6 inhibitor abemaciclib, which is used as anticancer drug, induces large vacuole formation in cytosol and causes cell death. In this study, we revealed that these large vacuoles induced by abemaciclib are swelling autolysosome. The vacuolar formation is independent of ATG5-related autophagy and is linked to cell death. It was also suggested that CDK4,6, main target of abemaciclib, functions as a target at least in part in the induction of vacuolar formation by abemaciclib. From these results, a part of mechanism in inducing large vacuolar formation in cytosol and in causing cell death is revealed.
Amount: ¥4,160,000
Funding type: fellowship
Funder scheme: Grant-in-Aid for Early-Career Scientists
Start date: 2018-04-01
End date: 2022-03-31
Investigator: Hirotsugu HINO
Institution: Nihon University(2019-2021)Tokyo Medical University(2018)
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Funded outputs count: 10
Funder award ID: 18K15031
OpenAlex ID: G4997868985