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Investigation of mechanisms for the regulation of CD8 T cell exhaustion by type 2 diabetic drug, metfromin

Description: We previously argued that type 2 diabetic drug, metformin has an anti tumor effect mediated by the modulation of CD8 T cell function. In this study, we investigated further mechanisms of the effect on several mouse tumor implantation model. These results revealed the activation of AMPK in antigen-specific CD8 T cell by metformin is quite important for tumor regression. Metformin-induced AMPK activation led to enhance an aerobic glycolysis of CD8 T cell through cell membrane translocation of amino acid transpoter, LAT1. These data indicated CD8 T cell metabolism has an critical role for anti-tumor effect of metformin.

Funder: Japan Society for the Promotion of Science

Amount: ¥4,160,000

Funding type: fellowship

Funder scheme: Grant-in-Aid for Young Scientists (B)

Start date: 2016-04-01

End date: 2018-03-31

Investigator: Shingo Eikawa

Institution: Okayama University

Topic: Metabolism, Diabetes, and Cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Funded outputs count: 1

Funder award ID: 16K18452

OpenAlex ID: G5000650611

Attenuation of CD4+CD25+ Regulatory T Cells in the Tumor Microenvironment by Metformin, a Type 2 Diabetes Drug

2017 · Yuki Kunisada, Shingo Eikawa, et al. · EBioMedicine · 150