A systems biology approach in Drosophila to identify novel factors that influence AD pathogenicity
Description: The risk that a person develops late-onset Alzheimer's Disease (AD) is influenced by a large number of genes, interacting in large, complex networks. To identify new pathways that cause AD, and to better understand how and why these pathways affect AD risk, this study uses a naturally variable population of fruit flies (the Drosophila Genome Reference Panel) to create a Systems Biology Pipeline for studying AD. This Pipeline will identify strains that are unusually resistant or sensitive to the toxic effects of proteins associated with AD, will use cutting edge technology to examine how molecular networks vary among these lines, and will study the biochemical, cellular, physiological and behavioral consequences of AD risk. Taken together, results from this study should lead to the discovery of novel causes and mechanisms of AD risk.
Funder: National Institute on Aging
Funding type: research
Funder scheme: RF1
Start date: 2017-09-15
End date: 2022-08-31
Investigator: DANIEL EDWARD PROMISLOW
Institution: UNIVERSITY OF WASHINGTON
Subfield: Physiology (medical)
Field: Medicine
Domain: Health Sciences
Funded outputs count: 13
Funder award ID: RF1AG057330
OpenAlex ID: G7491372359