Direct reprogramming of somatic cells by epithelial-mesenchymal transition
Description: Direct reprogramming, whereby cells are directly converted into another functional cell types, occurs primarily in mesenchymal cells but not readily in other somatic cells. In this study, our objective was to develop a direct reprogramming approach utilizing epithelial-mesenchymal transition (EMT) for various somatic cells. We identified transcription factors that induce EMT in keratinocytes, and demonstrated that the expression of SOX10, along with EMT induction, directly converted keratinocytes into neural crest-like cells. Additionally, we successfully converted mammary epithelial cells into neural crest-like cells using this method.
Amount: ¥4,420,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2018-04-01
End date: 2023-03-31
Investigator: Tsutomu Motohashi
Institution: Gifu University
Subfield: Molecular Biology
Domain: Life Sciences
Funded outputs count: 6
Funder award ID: 18K06826
OpenAlex ID: G5021901752