(Re)wiring a stem cell: Deciphering the molecular mechanism underpinning lineage propensity
Description: This project explores the response of the stem cells to cues that direct how they turn into specific type of cells that is suitable for clinical use. Specifically, a set of driver genes whose activity can foretell the outcome of cell differentiation will be identified. By modulating the maintenance conditions, iPSCs lines may be tailored for specific applications in stem cell therapy and disease modelling for the assessment of treatment efficacy.
Amount: A$855,800
Funding type: research
Funder scheme: Project Grants - Standard Project Grant
Start date: 2017-01-01
End date: 2019-12-31
Investigator: Patrick Tam
Institution: University of Sydney
Subfield: Molecular Biology
Domain: Life Sciences
Funded outputs count: 12
Funder award ID: 1127976
OpenAlex ID: G5034418282