Mechanism of progression of dementia and sarcopenia through gut-brain-muscle linkage mediated by monocytes and microglia
Description: We recognized the deterioration of intestinal microflora function and chronic inflammation, which is a risk for dementia and sarcopenia, in diabetic patients. In this study, we examined the pathogenesis of dementia and sarcopenia (gut-brain-muscle linkage) due to pathological interactions with the brain and muscle starting from the deterioration of the intestinal environment. In particular, we focused on function of monocyte/macrophage/microglia (M1/M2 polarity, TREM2) as a player of the pathological linkage, and found that serum sTREM2 is a predictive indicator of dementia and brain inflammation in the general population, diabetes mellitus and obese diabetic model mice. We generated TREM2-deficient mice to elucidate the mechanism of progression. In addition, we have clarified the effects of administration of diabetic drugs and flavonoids on the gut-brain-muscle interaction to establish optimal prophylaxis.
Amount: ¥6,370,000
Funding type: research
Funder scheme: Grant-in-Aid for Challenging Research (Exploratory)
Start date: 2018-06-29
End date: 2022-03-31
Investigator: Noriko Satoh-Asahara
Institution: Department of Clinical Research, National Hospital Organization Kyoto Medical Center
Funded outputs count: 22
Funder award ID: 18K19769
OpenAlex ID: G5037011848