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Mitochrondrial Etiologies of Parkinsons Disease

Funding type: program
Funder scheme: P50
Start date: 1999-09-30
End date: 2010-10-18
Investigator: JAMES PEPPER BENNETT
Institution: UNIVERSITY OF VIRGINIA
Funded outputs count: 44
Funder award ID: P50NS039788
OpenAlex ID: G4003285383
Mortality in Levodopa-Treated Parkinson's Disease
2014 · John C. Morgan, Lillian J. Currie, et al. · Parkinson s Disease · 42
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Mitochondrial quality, dynamics and functional capacity in Parkinson’s disease cybrid cell lines selected for Lewy body expression
2013 · Emily N Cronin-Furman, M Kathleen Borland, et al. · Molecular Neurodegeneration · 30
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RhTFAM treatment stimulates mitochondrial oxidative metabolism and improves memory in aged mice
2012 · Ravindar R. Thomas, Shaharyar M. Khan, et al. · Aging · 52
Impaired Complex-I Mitochondrial Biogenesis in Parkinson Disease Frontal Cortex
2012 · Ravindar R. Thomas, Paula M. Keeney, et al. · Journal of Parkinson s Disease · 58
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Mitochondrial gene replacement in human pluripotent stem cell-derived neural progenitors
2011 · S Iyer, E Xiao, et al. · Gene Therapy · 27
Handedness and motor symptom asymmetry in Parkinson's disease
2010 · M. J. Barrett, S. A. Wylie, et al. · Journal of Neurology Neurosurgery & Psychiatry · 98
Recombinant human mitochondrial transcription factor A stimulates mitochondrial biogenesis and ATP synthesis, improves motor function after MPTP, reduces oxidative stress and increases survival after endotoxin
2010 · Ravindar R. Thomas, Shaharyar M. Khan, et al. · Mitochondrion · 56
The Mitochondrial Secret(ase) of Alzheimer's Disease
2010 · Kisha J. Young, James P. Bennett · Journal of Alzheimer s Disease · 34
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Cybrid models of Parkinson's disease show variable mitochondrial biogenesis and genotype-respiration relationships
2009 · Paula M. Keeney, Lisa D. Dunham, et al. · Experimental Neurology · 35
Parkinson's disease brain mitochondria have impaired respirasome assembly, age-related increases in distribution of oxidative damage to mtDNA and no differences in heteroplasmic mtDNA mutation abundance
2009 · Charles R Arthur, Stephanie L Morton, et al. · Molecular Neurodegeneration · 61
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Mitochondrial Gene Therapy Augments Mitochondrial Physiology in a Parkinson's Disease Cell Model
2009 · Paula M. Keeney, Caitlin K. Quigley, et al. · Human Gene Therapy · 88
The cybrid model of sporadic Parkinson's disease
2009 · Patricia A. Trimmer, James P. Bennett · Experimental Neurology · 53
Recombinant mitochondrial transcription factor A with N-terminal mitochondrial transduction domain increases respiration and mitochondrial gene expression
2009 · Shilpa Iyer, Ravindar R. Thomas, et al. · Mitochondrion · 55
Reduced axonal transport in Parkinson's disease cybrid neurites is restored by light therapy
2009 · Patricia A Trimmer, Kathleen M Schwartz, et al. · Molecular Neurodegeneration · 117
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Chronic, low-dose rotenone reproduces Lewy neurites found in early stages of Parkinson's disease, reduces mitochondrial movement and slowly kills differentiated SH-SY5Y neural cells
2008 · M Kathleen Borland, Patricia A Trimmer, et al. · Molecular Neurodegeneration · 135
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UPDRS activity of daily living score as a marker of Parkinson's disease progression
2008 · Madaline B. Harrison, Scott A. Wylie, et al. · Movement Disorders · 88
Relationships among molecular genetic and respiratory properties of Parkinson's disease cybrid cells show similarities to Parkinson's brain tissues
2008 · M. Kathleen Borland, K.P. Mohanakumar, et al. · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 47
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Complex I deficiency in Parkinson's disease frontal cortex
2007 · W. Davis Parker, Janice K. Parks, et al. · Brain Research · 383
若者下位文化と社会的排除 ([スポーツ社会学]研究委員会企画論文 特集 スポーツの空間/空間のスポーツ)
2007 · 研之輔 田中 · スポーツ社会学研究
Parkinson's Disease Brain Mitochondrial Complex I Has Oxidatively Damaged Subunits and Is Functionally Impaired and Misassembled
2006 · Paula M. Keeney, Jing Xie, et al. · Journal of Neuroscience · 747
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Nitric oxide impairs mitochondrial movement in cortical neurons during hypoxia
2006 · Santina A. Zanelli, Patricia A. Trimmer, et al. · Journal of Neurochemistry · 60
Genetic algorithm for analysis of mutations in Parkinson's disease
2005 · Rafal Smigrodzki, Ben Goertzel, et al. · Artificial Intelligence in Medicine · 19
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Depression is associated with impairment of ADL, not motor function in Parkinson disease
2005 · Suzanne Holroyd, Lillian J. Currie, et al. · Neurology · 69
Altered intracellular signaling and reduced viability of Alzheimer's disease neuronal cybrids is reproduced by β-amyloid peptide acting through receptor for advanced glycation end products (RAGE)
2005 · Isaac G. Onyango, Jeremy B. Tuttle, et al. · Molecular and Cellular Neuroscience · 51
Brain-derived growth factor and glial cell line-derived growth factor use distinct intracellular signaling pathways to protect PD cybrids from HO-induced neuronal death
2005 · I ONYANGO, J TUTTLE, et al. · Neurobiology of Disease · 62
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