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Verbundprojekt: Neuro2D3 - Standardisierte Systeme zur Modellierung spät einsetzender neurologischer Erkrankungen und Wirkstoffscreening in 2D und 3D Kulturen - TP1 (Koordination)

Amount: €542,400
Funding type: grant
Funder scheme: Grundlagen der regenerativen Medizin
Start date: 2017-02-01
End date: 2020-01-31
Institution: Rheinische Friedrich-Wilhelms-Universität Bonn
Funded outputs count: 13
Funder award ID: 01EK1603A
OpenAlex ID: G5041298554
Protracted Fate Acquisition and Epigenetic De‐Aging During Induced Neural Stem Cell Conversion of Human Blood Cells
2026 · Lea Jessica Berg, Julia Franzen, et al. · Aging Cell
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Recapitulation of plaque formation, tau pathology, and neurodegeneration in a human 3D matrix model of Alzheimer’s disease
2026 · Matthias Hebisch, Viola Kamin, et al. · Cell Reports Methods · 1
Transcription Factor-Based Fate Specification and Forward Programming for Neural Regeneration
2020 · Lea J. Flitsch, Karen E. Laupman, et al. · Frontiers in Cellular Neuroscience · 55
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Evolving principles underlying neural lineage conversion and their relevance for biomedical translation
2019 · Lea Jessica Flitsch, Oliver Brüstle · F1000Research · 16
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Multiparametric rapid screening of neuronal process pathology for drug target identification in HSP patient-specific neurons
2019 · Kristina Rehbach, Jaideep Kesavan, et al. · Scientific Reports · 46
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Altered Levels of Proteins and Phosphoproteins, in the Absence of Early Causative Transcriptional Changes, Shape the Molecular Pathogenesis in the Brain of Young Presymptomatic Ki91 SCA3/MJD Mouse
2019 · Kalina Wiatr, Piotr Piasecki, et al. · Molecular Neurobiology · 20
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Induced pluripotent stem cell‐based modeling of mutant LRRK 2‐associated Parkinson's disease
2019 · Beatrice Weykopf, Simone Haupt, et al. · European Journal of Neuroscience · 30
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MicroRNAs Engage in Complex Circuits Regulating Adult Neurogenesis
2018 · Laura Stappert, Frederike Klaus, et al. · Frontiers in Neuroscience · 42
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A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation
2018 · Chao Sheng, Johannes Jungverdorben, et al. · Nature Communications · 59
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Assessment of established techniques to determine developmental and malignant potential of human pluripotent stem cells
2018 · The International Stem Cell Initiative, Thomas F. Allison, et al. · Nature Communications · 126
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Induced pluripotent stem cell-based modeling of neurodegenerative diseases: a focus on autophagy
2017 · Johannes Jungverdorben, Andreas Till, et al. · Journal of Molecular Medicine · 26
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Partial proteasome inhibition in human fibroblasts triggers accelerated M1 senescence or M2 crisis depending on p53 and Rb status
2008 · Niki Chondrogianni, Ioannis P. Trougakos, et al. · Aging Cell · 37
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