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PGC1alpha and Irisin in the Control of Diabetes and Obesity

Description: Diabetes and obesity take a major toll on health in the US. We have found a new polypeptide hormone that is produced by muscle with exercise and we will explore the molecular mechanisms by which this hormone increases energy expenditure and improves abnormalities in glucose homeostasis. This work has exciting promise for the development of new treatments for metabolic diseases and other disorders that are improved with exercise.
Funding type: research
Funder scheme: R01
Start date: 1998-09-10
End date: 2018-07-31
Investigator: BRUCE M. SPIEGELMAN
Institution: DANA-FARBER CANCER INST
Subfield: Physiology
Field: Medicine
Funded outputs count: 36
Funder award ID: R01DK054477
OpenAlex ID: G8908630521
Isolation of extracellular fluids reveals novel secreted bioactive proteins from muscle and fat tissues
2023 · Melanie J. Mittenbühler, Mark P. Jedrychowski, et al. · Cell Metabolism · 69
An Evolutionarily Conserved uORF Regulates PGC1α and Oxidative Metabolism in Mice, Flies, and Bluefin Tuna
2019 · Phillip A. Dumesic, Daniel F. Egan, et al. · Cell Metabolism · 47
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Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors
2018 · Hyeonwoo Kim, Christiane D. Wrann, et al. · Cell · 633
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The Cancer Drug Dasatinib Increases PGC-1α in Adipose Tissue but Has Adverse Effects on Glucose Tolerance in Obese Mice
2016 · Lykke Sylow, Jonathan Z. Long, et al. · Endocrinology · 8
The Secreted Enzyme PM20D1 Regulates Lipidated Amino Acid Uncouplers of Mitochondria
2016 · Jonathan Z. Long, Katrin J. Svensson, et al. · Cell · 256
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Detection and Quantitation of Circulating Human Irisin by Tandem Mass Spectrometry
2015 · Mark P. Jedrychowski, Christiane D. Wrann, et al. · Cell Metabolism · 558
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miR-222 Is Necessary for Exercise-Induced Cardiac Growth and Protects against Pathological Cardiac Remodeling
2015 · Xiaojun Liu, Junjie Xiao, et al. · Cell Metabolism · 390
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IRF4 Is a Key Thermogenic Transcriptional Partner of PGC-1α
2014 · Xingxing Kong, Alexander Banks, et al. · Cell · 313
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Irisin ERKs the Fat
2014 · Jun Wu, Bruce M. Spiegelman · Diabetes · 39
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Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway
2013 · Christiane D. Wrann, James P. White, et al. · Cell Metabolism · 1,426
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Development of insulin resistance in mice lacking PGC-1α in adipose tissues
2012 · Sandra Kleiner, Rina J. Mepani, et al. · Proceedings of the National Academy of Sciences · 288
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
2012 · Pontus Boström, Jun Wu, et al. · Nature · 4,788
Disorder-to-order transition underlies the structural basis for the assembly of a transcriptionally active PGC-1α/ERRγ complex
2011 · Srikripa Devarakonda, Kushol Gupta, et al. · Proceedings of the National Academy of Sciences · 69
Separation of the gluconeogenic and mitochondrial functions of PGC-1α through S6 kinase
2011 · Yaniv Lustig, Jorge L. Ruas, et al. · Genes & Development · 116
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The Unfolded Protein Response Mediates Adaptation to Exercise in Skeletal Muscle through a PGC-1α/ATF6α Complex
2011 · Jun Wu, Jorge L. Ruas, et al. · Cell Metabolism · 312
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C/EBPβ Controls Exercise-Induced Cardiac Growth and Protects against Pathological Cardiac Remodeling
2010 · Pontus Boström, Nina Mann, et al. · Cell · 412
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PGC-1α regulates a HIF2α-dependent switch in skeletal muscle fiber types
2010 · Kyle A. Rasbach, Rana K. Gupta, et al. · Proceedings of the National Academy of Sciences · 145
Retrograde influence of muscle fibers on their innervation revealed by a novel marker for slow motoneurons
2010 · Joe V. Chakkalakal, Hiroshi Nishimune, et al. · Development · 124
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Commentaries on Viewpoint: Gold standards for scientists who are conducting animal-based exercise studies
2010 · Christoph Handschin, Serge Summermatter, et al. · Journal of Applied Physiology · 27
RETRACTED: Increased muscle PGC-1α expression protects from sarcopenia and metabolic disease during aging
2009 · Tina Wenz, Susana G. Rossi, et al. · Proceedings of the National Academy of Sciences · 600
The role of exercise and PGC1α in inflammation and chronic disease
2008 · Christoph Handschin, Bruce M. Spiegelman · Nature · 1,084
Gene expression-based screening identifies microtubule inhibitors as inducers of PGC-1α and oxidative phosphorylation
2008 · Zoltan Arany, Bridget K. Wagner, et al. · Proceedings of the National Academy of Sciences · 82
HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α
2008 · Zoltan Arany, Shi-Yin Foo, et al. · Nature · 1,051
Abnormal glucose homeostasis in skeletal muscle–specific PGC-1α knockout mice reveals skeletal muscle–pancreatic β cell crosstalk
2007 · Christoph Handschin, Cheol Soo Choi, et al. · Journal of Clinical Investigation · 335
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Skeletal Muscle Fiber-type Switching, Exercise Intolerance, and Myopathy in PGC-1α Muscle-specific Knock-out Animals
2007 · Christoph Handschin, Sherry Chin, et al. · Journal of Biological Chemistry · 609
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