Molecular basis of transdifferentiation mechanism in type 2 diabetes mellitus ~for establishment of personalized therapy for type 2 diabetes~
Description: In the present study, we tried to establish the molecular basis of transdifferentiation of β cells in type 2 diabetes mellitus by elucidating " dependency of functional exhaustion on transdifferentiation" and "versatility of transdifferentiation". MIN6c4 cells, a mouse pancreatic β cell line, treated with high glucose and a certain type of fatty acid were subjected to various analysis from perspectives of acute or chronic stress. The most important result is data from transcriptome analysis which show differential expression pattern between acute and chronic stress.
Amount: ¥4,290,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2018-04-01
End date: 2023-03-31
Investigator: Naoyuki OKITA
Institution: Tokyo University of Science, Yamaguchi
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Funded outputs count: 11
Funder award ID: 18K11119
OpenAlex ID: G5085144530