Whole-body regeneration in Botrylloides leachii
Description: <style type='text/css'> P { margin-bottom: 0.08in; }</style><p style='text-align: justify;'><strong>Content and objectives of the research work</strong></p><p style='text-align: justify;'>This project utilizes an interdisciplinary approach combining techniques of imaging, image analysis, molecular biology and surgical manipulation. This novel approach will allow us to dissect several essential aspects of whole-body regeneration. In particular, we will:</p><ol> <li> <p style='text-align: justify;'> identify its cellular origin</p> </li> <li> <p style='text-align: justify;'> create an atlas of its cell types, lineages and migrations</p> </li> <li> <p style='text-align: justify;'> characterize the role of the surrounding vascular system</p> </li> <li> <p style='text-align: justify;'> establish the first study and culture center dedicated to <em>B. leachii</em></p> </li></ol><p style='text-align: justify;'><strong>Context of the research work</strong></p><p style='text-align: justify;'>Understanding how regeneration works and why it is present with different levels of importance in various organisms is crucial both for fundamental research as well as for potential therapeutical applications. This project will promote research in <em>B. leachii</em> and lay essential basis for the later functional characterization of whole-body regeneration. Altogether, this project aims at understanding how <em>Botrylloides leachii</em> can exceed cicatrization as we know it and thus open novel lines of research towards the reactivation of similar processes in vertebrates.</p>
Amount: CHF 1,045,000
Funding type: fellowship
Funder scheme: Ambizione
Start date: 2018-01-01
End date: 2022-03-31
Investigator: Blanchoud, Simon
Institution: University of Fribourg – FR
Funded outputs count: 3
Funder award ID: 173981
OpenAlex ID: G5111207763