Award

Health in pregnancy and beyond

Description: I will use advanced technologies to interrogate large pregnancy and birth cohorts to unravel the complex interactions between the mother, placenta and fetus and the woman’s environment to identify which combinations of factors contribute to the 4 common complications of pregnancy that can threaten the lives of mother and baby. I will advance implementation of the screening tests I have developed to predict risk in pregnant women to transform antenatal care and improve maternal and infant health.

Funder: National Health and Medical Research Council

Amount: A$2,078,000

Funding type: research

Funder scheme: Investigator Grants - Leadership

Investigator: Claire Roberts

Institution: University of Adelaide

Funded outputs count: 44

Funder award ID: 1174971

OpenAlex ID: G5111425002

Late-onset preeclampsia is characterized by accelerated placental aging

2026 · Anya L. Arthurs, Rudrarup Bhattacharjee, et al. · Proceedings of the National Academy of Sciences

Engineered trophoblast organoids recapitulate molecular and functional features of preeclampsia

2026 · Anya L Arthurs, Caleb Lushington, et al. · bioRxiv (Cold Spring Harbor Laboratory)

Excess folic acid disrupts placental endocrine function in vitro: a potential mechanism linking elevated folic acid exposure with gestational diabetes mellitus

2026 · Jessica M. Williamson, Anya L. Arthurs, et al. · Frontiers in Nutrition

High folic acid supplementation is associated with vaginal bleeding in early pregnancy in a fetal sex-specific manner: findings from two prospective cohort studies

2026 · Hongyan Wang, Shalem Leemaqz, et al. · Reproductive Health

Maternal Folate Excess, Placental Hormones, and Gestational Diabetes Mellitus: Findings from Prospective Cohorts Before and After Mandatory Folic Acid Food Fortification

2025 · Tanja Jankovic-Karasoulos, Melanie D. Smith, et al. · Nutrients · 4

Circular RNAs accumulate in aging human placental tissue and in stillbirth, leading to DNA damage and cellular senescence

2025 · Anya L. Arthurs, Matilda R. Jackson, et al. · American Journal of Obstetrics and Gynecology · 6

Pregnancy and Birth Trends Across Australia, the United States of America and the United Kingdom

2025 · Anya L. Arthurs, Jade K. Harrison, et al. · Journal of Clinical Medicine · 3

Sex‐specific effects of betamethasone on glucocorticoid and apoptotic signalling pathways in the sheep placenta

2025 · Ashley S. Meakin, Mitchell C. Lock, et al. · The Journal of Physiology · 3

Folate Overload and the Placental Hormone Axis: A Hidden Risk for Gestational Diabetes Mellitus

2025 · Tanja Jankovic-Karasoulos, Melanie D Smith, et al. · medRxiv · 2

Genetically edited human placental organoids cast new light on the role of ACE2

2025 · Anya L. Arthurs, Bianca Dietrich, et al. · Cell Death and Disease · 6

Treg cells promote decidual vascular remodeling and modulate uterine NK cells in pregnant mice

2024 · Shanna L. Hosking, Lachlan M. Moldenhauer, et al. · JCI Insight · 35

Asymmetric growth-limiting development of the female conceptus

2024 · Consuelo Amor S. Estrella, Kathryn L. Gatford, et al. · Frontiers in Endocrinology · 8

Placenta-Specific Transcripts Containing Androgen Response Elements Are Altered In Silico by Male Growth Outcomes

2024 · Ashley S. Meakin, Melanie Smith, et al. · International Journal of Molecular Sciences · 2

Factors influencing RNA yield from placenta tissue

2023 · Anya L. Arthurs, Dylan McCullough, et al. · Placenta · 6

Elevated Maternal Folate Status and Changes in Maternal Prolactin, Placental Lactogen and Placental Growth Hormone Following Folic Acid Food Fortification: Evidence from Two Prospective Pregnancy Cohorts

2023 · Tanja Jankovic-Karasoulos, Melanie D. Smith, et al. · Nutrients · 14

DraculR: A Web-Based Application for In Silico Haemolysis Detection in High-Throughput microRNA Sequencing Data

2023 · Melanie D. Smith, Shalem Y. Leemaqz, et al. · Genes · 3

Early pregnancy cardio metabolic risk factors and the prevalence of metabolic syndrome 10 years after the first pregnancy

2023 · Prabha H. Andraweera, Michelle D. Plummer, et al. · PLoS ONE · 5

A prospective registry analysis of psychosocial and metabolic health between women with and without metabolic syndrome after a complicated pregnancy

2022 · Emily Aldridge, K. Oliver Schubert, et al. · BMC Women s Health · 4

Women’s awareness of cardiovascular disease risk after complications of pregnancy

2022 · Emily Aldridge, Maleesa Pathirana, et al. · Women and Birth · 12

Effectiveness of a nurse practitioner-led cardiovascular prevention clinic at reduction of metabolic syndrome following maternal complications of pregnancy: a preliminary analysis

2022 · Emily Aldridge, Maleesa Pathirana, et al. · Diabetology & Metabolic Syndrome · 6

High Folate, Perturbed One-Carbon Metabolism and Gestational Diabetes Mellitus

2022 · Jessica M. Williamson, Anya L. Arthurs, et al. · Nutrients · 56

Haemolysis Detection in MicroRNA-Seq from Clinical Plasma Samples

2022 · Melanie D. Smith, Shalem Y. Leemaqz, et al. · Genes · 22

Pregnancy complications and cardiovascular disease risk perception: A qualitative study

2022 · Prabha H. Andraweera, Zohra S. Lassi, et al. · PLoS ONE · 12

Circular RNAs in Pregnancy and the Placenta

2022 · Anya L. Arthurs, Tanja Jankovic-Karasoulos, et al. · International Journal of Molecular Sciences · 14

Placental Transcription Profiling in 6–23 Weeks’ Gestation Reveals Differential Transcript Usage in Early Development

2022 · K. Justin Bogias, Stephen M Pederson, et al. · International Journal of Molecular Sciences · 9