Mechanisms by which C/EBPb inducues genome-wide H3K27ac during decidualization of human endometrial stromal cells
Description: C/EBPb regulates the expression of many decidualization-related genes through the genome-wide regulation of H3K27ac modification. In this study, we aimed to elucidate the detailed mechanism by which C/EBPb induces H3K27ac. We found that C/EBPb up-regulates the expression of PGC1a, which is an epigenetic transcription factor. In addition, C/EBPb forms a complex with PGC-1a and p300 to induce H3K27ac. Although the role of PGC-1a in the human endometrium has been unclear, our study demonstrated that PGC-1a contributes to decidualization by inducing epigenomic changes. Furthermore, PGC-1a may be involved in the immune regulation during decidualization.
Amount: ¥4,420,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2018-04-01
End date: 2021-03-31
Investigator: Isao TAMURA
Institution: Yamaguchi University
Funded outputs count: 10
Funder award ID: 18K09230
OpenAlex ID: G5160255441