Development and Application of Closed-Loop Artificial Pancreas
Description: n view of the increasing prevalence and morbidity of chronic diseases, such as diabetes, a regular drugs administration of subcutaneous injection of insulin are the most effective and direct therapy to reduce the complications of these diseases. However, the frequent drug application and potential risks of injection may result in low compliance of patients and thus decrease the therapeutic effectiveness. Therefore, to deal with this awkward situation, the development of a precision drug-delivery microsystem, integrated with a non-invasive physiological sensor for the measurement of blood glucose (BG), will be conducted to realize an autonomous drug-delivery microsystem in this project. In our preliminary works, a micropump system has been developed for delivering insulin to the diabetic rats. In this study, the flow stability and accuracy will be tested for a period of 1 week to 1 month with resolution of 10 nl/min dosing rate. Besides, the contact lens with physiological sensors will be developed for long-term and real time measurements of glucose concentration of tears. For verifying the reliability and accuracy of BG computation from tears, the clinical trials will be first conducted to study the glucose-level correlation of bio-fluids, including tears, interstitial fluid, and blood in the first year. With such biomedical contact lens patients or even healthy people could be beneficial for disease or health monitoring and diagnosis. In the second year, a series of animal tests of insulin therapy to diabetic rats will be conducted to verify the efficacy and safety of developed drug delivery system before clinical trials in the second year. This newly developed system brings the benefit in eliminating the low compliance of drug application and fear of regular and frequent subcutaneous injections, and thus could greatly enhance the therapeutic quality. In the final year, an artificial pancreas, consisting of self-developed drug delivery system and BG-detecting contact lens system, will be realized to study its closed-looped algorithm by animal tests before the clinical trials. Comparing the commercial products with the present autonomous drug-delivery system developed in the project, a bench mark test would be made at the end.
Amount: TWD 2,757,000
Funding type: research
Funder scheme: 學術補助
Investigator: 曾慶孝
Institution: 國立臺灣大學醫學院內科
Funded outputs count: 10
Funder award ID: MOST107-2221-E002-129-MY3
OpenAlex ID: G5184738398