Metabolic regulation of human DNA methylation clocks
Description: NARRATIVE Epigenetic clocks are widely used in geroscience but little known about their modifiability and behavior across the lifespan. Here we use a human cellular lifespan system that recapitulates key hallmarks of human aging (DNA methylation signatures, ccf-mtDNA, inflammation) to map individualized trajectories in the rate of epigenetic aging among cells from healthy women and men, in response to glucocorticoid stress, and to targeted mitochondrial dysfunction. These high-resolution longitudinal multi-system data will provide new insights into inter-individual differences in aging trajectories, the modifiability of epigenetic clocks, and provide causal evidence for the of mitochondrial dysfunction as a potential biological determinant of epigenetic aging.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R01
Start date: 2020-04-15
End date: 2025-12-31
Investigator: MARTIN PICARD
Institution: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
Subfield: Molecular Biology
Domain: Life Sciences
Funded outputs count: 34
Funder award ID: R01AG066828
OpenAlex ID: G6975462085