Development of functional food for the elderly in terms of oral care and prevention/improvement of osteoporosis and various metabolic disorders
Description: In the present study, grape seed extract (GSE) containing high concentration of proanthocyanidin inhibited inflammatory response of human gingival fibroblasts in vitro. In addition, GSE improved lowered bone density and delayed bone healing as well as obesity and disturbed glucose metabolism in ovariectomized animals. These results suggest that GSE have an ability to protect human oral cells from inflammatory stimuli and to improve metabolic syndrome-like disorder and disturbed bone metabolism such as osteoporosis in postmenopausal women. However, I could not conclude whether the action of GSE is exerted via changes in gut microbiota because of high fluctuation in analytical data of the microbiota. The possible involvement of gut microbiota in GSE’s action is to be further studied.
Amount: ¥4,810,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2017-04-01
End date: 2020-03-31
Investigator: Yoshimi Niwano
Institution: Shumei University(2018-2019)Tohoku University(2017)
Funded outputs count: 14
Funder award ID: 17K07788
OpenAlex ID: G5194429205