Identification of novel mediators of age-associated chronic inflammation and cancer development through targeted proteomics
Description: Cancer is a leading cause of death worldwide and aging ls considered one of the most important risk factors for cancer. Aging is characterized by chronic low-grade inflammation and oxidant damage, which lead to endothelial senescence and disruption of vascular function. Inflammatory mediators released from senescent endothelial cells contribute to cancer by promoting mutations in neighboring cells and resistance to apoptosis through induction of oncogenes, resulting in deregulated growth. The precise mechanisms that link age-associated chronic inflammation to cancer remain to be identified. Our goal is to investigate progressive molecular changes that occur during development of endothelial senescence-associated pro-inflammatory phenotype and identify potential regulators involved in inflammation and cancer during aging. The proto-oncogene c-Myc is ubiquitously expressed in different cell types and plays an important role in tissue homeostasis. Deregulated c-Myc expression is found in most types of cancer. Interestingly, preliminary findings on over expression of c-Myc specifically in mouse endothelial cells resolve age-associated inflammation and down-regulates cancer markers like Snail and Twist in a tissue-specific manner. The current proposal provides the unique opportunity to combine the expertise of Dr. Rodrigues in c-Myc and vascular inflammation and Dr. Faça in targeted proteomic to identify novel molecular regulators of age-associated inflammation specifically related to cancer. (AU)
Funding type: grant
Funder scheme: Auxílio à Pesquisa - Regular
Start date: 2017-07-01
End date: 2018-09-30
Investigator: Vitor Marcel Faça
Institution: Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP)
Funded outputs count: 0
Funder award ID: 17/50031-0
OpenAlex ID: G5223062681