Regulation of Hematopoietic Progenitors by de novo DNA Methylation
Description: Project Narrative We have found that proteins which alter the structure of DNA (DNA methyltransferases) can help regulate the ability of these blood forming stem cells to make blood. These proteins are often dysregulated with age, correlating with the dysregulated blood production. Understanding how these proteins regulate stem cells and blood production may improve bone marrow transplantation and lend insight into development of myelodysplastic syndromes.
Funding type: research
Funder scheme: R56
Start date: 2011-07-01
End date: 2012-06-30
Investigator: MARGARET A. GOODELL
Institution: BAYLOR COLLEGE OF MEDICINE
Funded outputs count: 52
Funder award ID: R56DK092883
OpenAlex ID: G3769525199