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UNC Neuroscience Center Research Cores

Description: “UNC Neuroscience Center Research Cores” (P30 NS045892-14) supports almost all NINDS-funded research at the UNC–Chapel Hill School of Medicine. We request continued support for Cores that provide cutting edge resources in Microscopy and Bioinformatics. These Cores provide the tools that our NINDS-funded investigators need to conduct research directed at curing neurological diseases.
Funding type: program
Funder scheme: P30
Start date: 2003-07-01
End date: 2022-11-30
Investigator: MARK J. ZYLKA (lead)
Institutions: University of North Carolina at Chapel Hill, UNIV OF NORTH CAROLINA CHAPEL HILL
Subfield: Biophysics
Funded outputs count: 363
Funder award ID: P30NS045892
OpenAlex ID: G4901553375
Age-related hearing loss begins with gain, not silence: physiological compensation in dorsal cochlear nucleus fusiform cells during auditory aging
2026 · Reginald J. Edwards, Michael R. Kasten, et al. · Journal of Neurophysiology
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A suite of engineered mice for interrogating psychedelic drug actions
2026 · Yi-Ting Chiu, Ariel Y. Deutch, et al. · Nature Neuroscience · 20
Inhibition of DNA demethylation attenuates experimental necrotizing enterocolitis via suppression of TLR4-mediated inflammation
2026 · Yukihiro Yamaguchi, Vikram Puri, et al. · Research Square
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Autoantigen-loaded Polymeric Microparticles associate with B cells and promote tolerogenic antigen presentation in a mouse model of experimental autoimmune encephalomyelitis
2026 · Nicole Rose Lukesh, Brian G. Barbery, et al. · Nature Communications · 1
Perfluorooctanoic acid (PFOA) induces lipid accumulation, oxidative stress, and reduced neurogenesis in primary human neuronal progenitor cells
2026 · William P. Marinello, Mark J. Zylka · Frontiers in Toxicology
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Injectable thermoresponsive hydrogel scaffold for enhanced delivery of next-generation induced neural stem cells for treatment of glioblastoma
2026 · Kayla M. Maue, Nour Caroline Dau, et al. · Drug Delivery and Translational Research
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CORE: Cholesterol Altered Lipid Nanoparticles for Splenic Expression of mRNA Payloads
2026 · Eshan A. Narasipura, Vincent Fung, et al. · Advanced Healthcare Materials · 5
Disrupted O-GalNAc glycosylation as a mechanism and biomarker of SLC35A2 -associated epilepsy
2026 · Robert G. Mealer, James J. Anderson, et al. · bioRxiv (Cold Spring Harbor Laboratory)
Chd8 haploinsufficiency leads to molecular layer heterotopias and age-dependent cortical expansion
2026 · Felix A Kyere, Ian Curtin, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 3
A dual-reporter mouse for therapeutic discovery in Angelman syndrome
2026 · Hanna Vihma, Lucas M. James, et al. · JCI Insight · 2
Human cortical organoids recapitulate inter-individual variability in infant brain-growth trajectories
2025 · Madison R. Glass, Nana Matoba, et al. · Cell stem cell · 12
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Neurosteroid (3α,5α)3-hydroxypregnan-20-one enhancement of anti-inflammatory chemokine CX3CL1 exhibits sex, brain region, and cellular specificity in alcohol-preferring rats
2025 · Samantha Lucenell Chéry, Baylee R. Materia, et al. · Psychopharmacology
Lipid packing and local geometry influence septin curvature sensing
2025 · Brandy N. Curtis, Ellysa J.D. Vogt, et al. · The Journal of Cell Biology · 5
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Targeting glucose-inhibited hippocampal CCK interneurons prevents cognitive impairment in diet-induced obesity
2025 · Taylor Landry, Laura Perrault, et al. · Neuron · 7
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Single nucleus RNA sequencing of the cerebral cortex from genetically diverse inbred mouse strains reveals differences in pericyte and endothelial cell composition
2025 · Jieun Park, Bonnie Taylor-Blake, et al. · PLoS ONE · 1
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Long-Range Dipole Alignment of Molecules Generates Strong Local Electric Fields at Air–Water Interfaces
2025 · Alessandra Mandala Kol, Teddy Herriman, et al. · ChemRxiv · 3
Noncanonical short-latency auditory pathway directly activates deep cortical layers
2025 · Michellee M. Garcia, Amber M. Kline, et al. · Nature Communications · 12
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Customizable Polymeric Nanoparticle Materials Optimized on Hypoxic Cells Facilitate mRNA Expression in the Lungs In Vivo
2025 · Palas Balakdas Tiwade, Vincent Fung, et al. · Advanced Healthcare Materials · 11
SLC35A2 loss-of-function variants affect glycomic signatures, neuronal fate and network dynamics
2025 · Dulcie Lai, Paulina Sosicka, et al. · Brain · 14
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Development of DNase‐1 Loaded Polymeric Nanoparticles Synthesized by Inverse Flash Nanoprecipitation for Neutrophil‐Mediated Drug Delivery to In Vitro Thrombi
2025 · Sophie Maiocchi, Erica E. Burnham, et al. · Advanced Healthcare Materials · 18
Identifying environmental chemicals impacting neurodevelopment using a random mixture-based screening approach
2025 · Wenxin Hu, Lei Xing, et al. · Toxicological Sciences · 4
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A Metabolite Co-Delivery Strategy to Improve mRNA Lipid Nanoparticle Delivery
2025 · Yutian Ma, Vincent Fung, et al. · ACS Applied Materials & Interfaces · 12
Long-Range Dipole Alignment of Molecules Generates Strong Local Electric Fields at Air–Water Interfaces
2025 · Alessandra Mandala Kol, Teddy Herriman, et al. · ChemRxiv
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mRNA lipid nanoparticle formulation, characterization and evaluation
2025 · Yutian Ma, Rachel VanKeulen-Miller, et al. · Nature Protocols · 72
Comparative profiling of white matter development in the human and mouse brain reveals volumetric deficits and delayed myelination in Angelman syndrome
2024 · Siddhi S. Ozarkar, Ridthi K.-R. Patel, et al. · Molecular Autism · 10
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