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Development and optimization of cell based cryopreservation models

Description: agent based model; Cell line; Cost function; Cryobiology; Cryopreservation; Damage hypotheses; embryonic stem cell; islet of langerhans; Iterative optimization; systems biology
Amount: CA$56,000
Funding type: research
Funder scheme: Discovery Grants Program - Individual
Start date: 2021-04-01
End date: 2022-03-31
Investigator: James Benson
Institution: University of Saskatchewan
Funded outputs count: 12
Funder award ID: rgpin-2017-06346
OpenAlex ID: G5276379861
Application of portable cryodevice as a solution for centralized cryobanking
2023 · Atefeh Najafi, Ebrahim Asadi, et al. · Cryobiology
Rational synthesis of total damage during cryoprotectant equilibration: modelling and experimental validation of osmomechanical, temperature, and cytotoxic damage in sea urchin ( Paracentrotus lividus ) oocytes
2023 · Dominic J. Olver, Pablo Heres, et al. · PeerJ · 11
An impedance based microfluidic sensor for evaluation of individual red blood cell solute permeability
2023 · Lining Huang, Ibrahim Jasim, et al. · Analytica Chimica Acta · 5
Technologies for Vitrification Based Cryopreservation
2023 · Mohammad Amini, James D. Benson · Bioengineering · 48
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Real-time computer assisted measurement of oocyte and embryo volume for assessment of transport parameters
2022 · Frankie Tu, Maajid Bhat, et al. · Cryobiology · 7
Time dependent osmotic damage in sea urchin oocytes
2020 · Dominic Olver, Pablo Heres, et al. · Cryobiology
Robust numerical solution for the two parameter solute solvent transport model
2020 · James D. Benson · Cryobiology · 2
Implications of variability in cell membrane permeability for design of methods to remove glycerol from frozen-thawed erythrocytes
2020 · John M. Lahmann, Cynthia Cruz Sanchez, et al. · Cryobiology · 14
A Toxicity Cost Function Approach To Optimal Cpa Equilibration In Tissues
2019 · James Benson, Adam Z. Higgins, et al. · Cryobiology
Foundations of modeling in cryobiology—III: Inward solidification of a ternary solution towards a permeable spherical cell in the dilute limit
2019 · Daniel M. Anderson, James D. Benson, et al. · Cryobiology · 18
Concentration dependence of the cell membrane permeability to cryoprotectant and water and implications for design of methods for post-thaw washing of human erythrocytes
2017 · John M. Lahmann, James D. Benson, et al. · Cryobiology · 28
A toxicity cost function approach to optimal CPA equilibration in tissues
2017 · James D. Benson, Adam Z. Higgins, et al. · Cryobiology · 47
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